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Research Paper

Biocompatible Bacterial Cellulose Composites for Biomedical Application

[+] Author and Article Information
Jaehwan Kim

Department of Mechanical Engineering, Center for EAPap Actuator, Inha University, 253 Yonghyun-Dong, Nam-Ku, Incheon 402-751, South Koreajaehwan@inha.ac.kr

Zhijiang Cai, Yi Chen

Department of Mechanical Engineering, Center for EAPap Actuator, Inha University, 253 Yonghyun-Dong, Nam-Ku, Incheon 402-751, South Korea

J. Nanotechnol. Eng. Med 1(1), 011006 (Oct 29, 2009) (7 pages) doi:10.1115/1.4000062 History: Received April 09, 2009; Revised August 11, 2009; Published October 29, 2009

This paper reports bacterial cellulose composites made by blending chitosan, poly(ethylene glycol) (PEG), and gelatin for potential biomedical application of tissue-engineering scaffold and wound-dressing material. The bacterial cellulose composites were successfully prepared by immersing a wet bacterial cellulose pellicle into chitosan, PEG, or gelatin solutions followed by freeze-drying. The products look like a foam structure. Scanning electron microscopy images show that chitosan molecules penetrated into bacterial cellulose forming a multilayer and a well interconnected porous network structure with a large aspect surface. The morphology of the bacterial cellulose/gelatin scaffold indicates that the gelatin molecules could penetrate well between the individual nanofibers of the bacterial cellulose. Cell adhesion studies for these composites were carried out using 3T3 fibroblast cells. They showed much better biocompatibility than pure bacterial cellulose. Preparation and material characterization of these composites are explained.

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Figures

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Figure 1

Bacterial cellulose: (a) wet gel, (b) cross-sectional SEM image (×1000), (c) surface SEM image (×10,000), and (d) surface SEM image (×60,000)

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Figure 2

SEM images of BC composite blends: ((a), (c), and (e)) (top line): surface images of BC/chitosan, BC/PEG, and BC/gelatin composites; ((b), (d), and (f)) (bottom line): cross-sectional images of BC/chitosan, BC/PEG, and BC/gelatin composites

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Figure 3

FTIR spectra of BC, BC/chitosan, BC/PEG, and BC/gelatin composites

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Figure 4

XRD patterns for BC, BC/chitosan, BC/PEG, and BC/gelatin composites

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Figure 5

TGA curves for BC, BC/chitosan, BC/PEG, and BC/gelatin composites

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Figure 6

The effect of chitosan content on the thermal degradation temperature and weight loss at 250°C of BC/chitosan composites

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Figure 7

SEM images of cell attachment on: (a) pure BC, (b) BC/chitosan, (c) BC/PEG and (d) BC/gelatin composites

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