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Research Papers

Separation of Particles for Drug Delivery Using a Microfluidic Device With Actuation

[+] Author and Article Information
Guoguang Su

Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA 23284

Ramana M. Pidaparti1

Department of Mechanical Engineering, Virginia Commonwealth University, Richmond, VA 23284rmpidaparti@vcu.edu

1

Corresponding author.

J. Nanotechnol. Eng. Med 2(2), 021006 (May 16, 2011) (8 pages) doi:10.1115/1.4003930 History: Received March 02, 2011; Revised March 15, 2011; Published May 16, 2011; Online May 16, 2011

The purpose of this study is to demonstrate particle separation through a novel mechanism termed as “time series alternate flow” using a microdevice as it is a real challenge to separate particles with a narrow size range (i.e., 110μm or smaller), especially achieving particles separation through the hydrodynamic method without the help from additional flow or force fields. High fidelity computational fluid dynamics with particle trajectory approach was employed for simulations. Particle separation of different sizes in the range 210μm size was achieved by operating the microdevice at various actuating frequencies. The results obtained indicated that the proposed mechanism is feasible for particle separation of multiple sizes. Our novel mechanism proposed potentially represents a viable microtechnological approach for particle separation in many drug delivery applications.

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Copyright © 2011 by American Society of Mechanical Engineers
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Figures

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Figure 1

An overview of existing particle separation mechanisms: (a) hydrodynamic, (b) with additional flow field, and (c) with additional force field

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Figure 2

Proposed mechanism for particle separation in comparison with traditional hydrodynamic mechanism: (a) hydrodynamic approach and (b) proposed approach

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Figure 3

A schematic of the microfluidic system for (a) particle separation and the computational grid (b) for numerical simulation

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Figure 4

Instantaneous streamlines and particle location at the beginning for 1000 kHz actuation frequency

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Figure 5

Instantaneous streamlines and particle location over a period at intermediate stage for 1000 kHz actuation frequency

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Figure 6

Particles location at different times for micropump actuating at 1000 kHz frequency

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Figure 7

Particle separation of 10 μm (top), 5 μm (middle), and 2.5 μm (bottom) using different actuating frequencies of the micropump

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Figure 8

Effect of actuation frequency (kHz) on particle size separation. Larger particles separate at lower frequencies and vice versa.

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Figure 9

Percentage of particles of different sizes separated at the outlet of the micropump for various actuation frequencies

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