Technical Briefs

Microcantilever Based Microdiagnostic Kit for Biomedical Applications: A Cost-Benefit Outlook

[+] Author and Article Information
Sree Vidhya

 Frost and Sullivan, 6th Floor, Karumuttu Centre, 498 Anna Salai, Nandanam, Chennai 600035 Indiaesreevidhya@gmail.com

Gideon Praveen Kumar, Lazar Mathew

School of Biosciences and Technology, VIT University, Vellore 632014 India

J. Nanotechnol. Eng. Med 1(3), 034501 (Aug 11, 2010) (3 pages) doi:10.1115/1.4001790 History: Received March 23, 2010; Revised March 30, 2010; Published August 11, 2010; Online August 11, 2010

Piezoresistive actuation of a microcantilever induced by biomolecular binding such as DNA hybridization and antibody-antigen binding is an important principle useful in biosensing applications. As the magnitude of the forces exerted is small, increasing the sensitivity of the microcantilever becomes critical. In this paper, we are considering to achieve this by geometric variation of the cantilever. The sensitivity of the cantilever was improved so that the device can sense the presence of the antigen even if the magnitude of surface stresses over the microcantilever was very small. We consider a “T-shaped” cantilever that eliminates the disadvantages while improving the sensitivity simultaneously. An analysis of the cantilever using stainless steel and silicon has been performed using INTELLISUITE software (a microelectromechanical systems design and simulation package).

Copyright © 2010 by American Society of Mechanical Engineers
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Grahic Jump Location
Figure 1

T-shaped cantilever

Grahic Jump Location
Figure 2

Cantilever within a rigid frame

Grahic Jump Location
Figure 3

Biosensor design using computer aided design (CAD)




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