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Research Paper

Magnetic Drug Targeting in Partly Occluded Blood Vessels Using Magnetic Microspheres

[+] Author and Article Information
Moloy K. Banerjee

Department of Mechanical Engineering, Future Institute of Engineering and Management, Kolkata 700150, Indiamoloy_kb@yahoo.com

Amitava Datta

Department of Power Engineering, Jadavpur University, Kolkata 700098, Indiaamdatta_ju@yahoo.com

Ranjan Ganguly1

Department of Power Engineering, Jadavpur University, Kolkata 700098, Indiaranjan@pe.jusl.ac.in

1

Corresponding author.

J. Nanotechnol. Eng. Med 1(4), 041005 (Oct 21, 2010) (9 pages) doi:10.1115/1.4002418 History: Received July 28, 2010; Revised August 16, 2010; Published October 21, 2010; Online October 21, 2010

Magnetic drug targeting can be used for treating stenosis and thrombosis in partly occluded blood vessels. Herein, a numerical investigation of magnetic drug targeting using functionalized magnetic microspheres in partly occluded blood vessels is conducted. An Eulerian-Lagrangian technique is adopted to resolve the hemodynamic flow and the motion of the magnetic particles in the flow. An implantable cylindrical permanent magnet insert is used to create the requisite magnetic field. Targeted transport of the magnetic particles in a partly occluded vessel differs distinctly from the same in a regular unblocked vessel. Parametric investigation is conducted, and the influence of the flow Re, magnetic insert diameter, and its radial and axial position on the “targeting efficiency” is reported. Analysis shows that there exists an optimum regime of operating parameters for which deposition of the drug-carrying magnetic particles in a predesignated target zone on the partly occluded vessel wall can be maximized. The results provide useful design bases for an in vitro setup for the investigation of magnetic drug targeting in stenosed blood vessels.

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Copyright © 2010 by American Society of Mechanical Engineers
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Figures

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Figure 1

(a) Geometrical configuration of the occlusion with the cylindrical magnet for drug targeting. (b) Magnetic field produced by the insert (flux lines superposed on the |H| contours).

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Figure 2

Streamline patterns for flow through a partly occluded vessel for Re=5 and S=50%

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Figure 3

Particle trajectories on the vertical plane for the base case (Ms=1.2×106 A/m, Rm=0.001 m=2d, rmag=0.001255 m, and zmag=0.0025 m)

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Figure 4

(a) Particle capture histogram (considering all the 11 Δθ sectors within the azimuthal zone of −π/2≤θ≤−π/2) along the length of the blood vessel for the base case shown in Fig. 3. Inset shows the azimuthal capture histogram at z=5.25d for the 11 Δθ sectors. (b) Particle capture histogram along different θ planes for the base case.

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Figure 5

Particle trajectories containing the θ=−π/2 and θ=π/2 planes in the partly occluded vessel under different flow Re. The region 3.35≤z/d≤5.75 is defined as the ZC in the figures. For all the cases, Ms=1.2×106 A/m, Rm=0.001 m, rmag=2.51d, and zmag=5d.

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Figure 6

Variation in TE with Re (Ms=1.2×106 A/m, Rm=0.001 m, rmag=2.51d, and zmag=5d)

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Figure 7

Variation in TE with the radius of magnetic insert (Re=5, Ms=1.2×106 A/m, rmag=2.51d, and zmag=5d)

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Figure 8

Variation in TE with δ for different values of flow Re (Ms=1.2×106 A/m, Rm=0.001 m, and zmag=5d)

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Figure 9

Variation in TE with zmag for different values of flow Re (Ms=1.2×106 A/m, Rm=0.001 m, and rmag=2.51d)

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