In this work, an extensive experimental data of Nansulate coating from NanoTechInc were applied to develop an artificial neural network (ANN) model. The Levenberg–Marquart algorithm has been used in network training to predict and calculate the energy gain and energy saving of Nansulate coating. By comparing the obtained results from ANN model with experimental data, it was observed that there is more qualitative and quantitative agreement between ANN model values and experimental data results. Furthermore, the developed ANN model shows more accurate prediction over a wide range of operating conditions. Also, maximum relative error of 3% was observed by comparison of experimental and ANN simulation results.