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Research Papers

Generating Nanoparticles for Respiratory Drug Delivery

[+] Author and Article Information
Guoguang Su

Department of Mechanical Engineering,  Virginia Commonwealth University, Richmond, VA 23284

Ramana M. Pidaparti1

Department of Mechanical Engineering,  Virginia Commonwealth University, Richmond, VA 23284rmpidaparti@vcu.edu

1

Corresponding author.

J. Nanotechnol. Eng. Med 2(3), 031010 (Jan 20, 2012) (8 pages) doi:10.1115/1.4005488 History: Received July 07, 2011; Revised August 22, 2011; Published January 20, 2012; Online January 20, 2012

Generating liquid droplets is ideal for many applications including respiratory drug delivery because the droplets have uniform properties and can be easily controlled, sampled, and analyzed. In this study, a micropump-based droplet generator is proposed to produce the liquid droplets of micron to nano size. Numerical simulations were carried out to evaluate the ability of the proposed droplet generator device to produce liquid droplets. The velocity and diameter of the droplets generated by the droplet generator device were calculated, and the performance of the device’s flow rate and power consumption was evaluated. The effects of actuation frequency, actuation modes, and nozzle geometry on the performance of the device were investigated. Results showed that the proposed device can produce micron-/nano-sized liquid droplets with low power and the advantages of the proposed droplet generator device over traditional devices were discussed.

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Copyright © 2011 by American Society of Mechanical Engineers
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Figures

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Figure 1

Typical drug delivery approaches for human respiratory system

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Figure 2

Sketch of the proposed micropump-based droplet generator system

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Figure 3

Numerical grid for computational analysis of droplets generation

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Figure 4

Flow field around droplets near the exit of the micropump

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Figure 5

Temporal evolution of liquid droplets ejected by the micropump at an actuation frequency of 1 MHz

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Figure 6

Instantaneous liquid droplets ejected by the micropump with different nozzle diameters

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Figure 7

Effect of nozzle diameter of micropump on the droplet velocity and volume flow

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Figure 8

Instantaneous liquid droplets ejected by the micropump at the 30th vibration cycles for different actuation frequencies

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Figure 9

Effect of actuation frequency of micropump on the droplet velocity and volume flow

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Figure 10

Effect of actuation frequency of micropump on the power consumption

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Figure 11

Instantaneous liquid droplets ejected by the micropump with different actuation modes

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Figure 12

Effect of actuation modes on the droplet velocity and volume flow

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