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Research Papers

Novel Natural Transdermal Otoliths/Collagen/Bacterial Cellulose Patch for Osteoporosis Treatment

[+] Author and Article Information
Gabriel Molina de Olyveira, Ligia Maria Manzine Costa

 Department of Nanoscience and Advanced Materials-UFABC, Rua Santa Adélia, 166, Santo André-SP, Brazil, 09291-210

Plácia Barreto Prata Góis, Lauro Xavier Filho

Natural Products and Biotechnology Laboratory, IPT, UNIT, Aracaju-Sergipe, Brazil, 49.032-490

Pierre Basmaji

 Innovatec’s - Biotechnology Research and Development, Sao Carlos, SP, Brazil, 13566-610

J. Nanotechnol. Eng. Med 2(3), 031011 (Jan 26, 2012) (4 pages) doi:10.1115/1.4004306 History: Received April 24, 2011; Revised May 17, 2011; Published January 26, 2012; Online January 26, 2012

In the present work, we report the novel natural transdermal otoliths/collagen/bacterial cellulose patch for osteoporosis treatment. This biomaterial is an osteoinductor, or be, stimulates the bone regeneration, enabling bigger migration of the cells for formation of the bone fabric. Otolith is a typical biomaterial that is composed of calcium carbonate and organic matrix. Otoliths are calcareous concrescences present in the inner ear of fishes. Since they are rich in minerals, they are considered essential to the bone mineralization process on a protein matrix (otolin). The objective in this study was to analyze the regeneration capacity of bone defects treated with otoliths network preparation. Collagen and nano-otoliths influences in bacterial cellulose was analyzed using transmission infrared spectroscopy (FTIR). In vivo analysis shows bone surface tissue with high regularity, higher osteoblast activity, and osteo-reabsorption activities areas. These results indicated that the transdermal permeation of otollith using this patch system was sufficient for the treatment of bone diseases. These findings indicate that our novel transdermal delivery system for otolith/collagen/bacterial cellulose is a promising approach to improve compliance and quality of life of patients in the treatment of bone diseases.

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Copyright © 2011 by American Society of Mechanical Engineers
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Figures

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Figure 1

SEM (a) and TEM (b) of pure bacterial cellulose (sample a, as a reference)

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Figure 2

Bacterial cellulose mats with collagen

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Figure 3

Bacterial cellulose mats with otoliths/collagen

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Figure 4

FTIR spectra of the samples BC and BC/collagen

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Figure 5

FTIR spectra of the samples BC, BC/collagen, and BC/collagen/otoliths

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Figure 6

FTIR spectra of the samples BC and BC/nano-otoliths

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Figure 7

(a) Showing bone reabsorption areas (hematoxylin and eosin stain—H&E); (b) Evidence of osteo- reabsorption activities areas. These results indicated that the transdermal permeation of otollith using this patch system was sufficient for the treatment of bone diseases.These findings indicate that our novel transdermal delivery system for otolith/collagen/BC is a promising approach to improve compliance and quality of life of patients in the treatment of bone diseases.

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