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Research Papers

Synthesis and Antibacterial Activity of Silver Nanoparticles Embedded in Smart Poly(N-Isopropylacrylamide)-Based Hydrogel Networks

[+] Author and Article Information
Fereshteh Valipour, Majid Esmhosseini, Kamelia Nejati, Hasan Kianfar, Ardalan Pasdaran

Drug Applied Research Center,  Tabriz University of Medical Sciences, P.O. Box 51656‐75913, Tabriz, IranDepartment of Chemistry of Science, P.O. Box 165‐57153,  Uremia University, Uremia, IranDepartment of Chemistry,  Payame Nour University of Tabriz, P.O. Box 19395‐3697, Tabriz, IranTalent Students Office, Education Development Center, Student Research Committee,  Tabriz University of Medical Science, P.O. Box 51656‐75913, Tabriz, Iran

Soodabeh Davaran1

Research Center for Pharmaceutical Nanotechnology,  Tabriz University of Medical Sciences, P.O. Box 51656‐75913, Tabriz, Irandavaran@tbzmed.ac.ir

1

Corresponding author.

J. Nanotechnol. Eng. Med 2(4), 041001 (Apr 04, 2012) (7 pages) doi:10.1115/1.4005677 History: Received April 17, 2011; Accepted May 23, 2011; Published March 30, 2012; Online April 04, 2012

In recent study, we report the synthesis and antibacterial activity of silver nanoparticles embedded in smart poly(N-isopropylacrylamide)-based hydrogel networks. A series of thermosensitive poly(N-isopropylacrylamide-methacrylic acid-hydroxyethyl methacrylate) [P(NIPAAm-MAA-HEM)] with various cross-linking ratio have been obtained by cross-linking free radical polymerization of N-isopropylacrylamide (NIPAAm), methacrylic acid (MAA), and hydroxyethyl methacrylate (HEM) in the presence of triethyleneglycol dimethacrylate (TEGDMA) as cross-linker. Highly stable and uniformly distributed silver nanoparticles have been obtained with hydrogel networks via in situ reduction of silver nitrate (AgNO3 ) using sodium borohydride (NaBH4 ) as reducing agent. The formation of silver nanoparticles has been confirmed with ultraviolet visible (UV–Vis) spectroscopy. Scanning electron microscopy (SEM) results demonstrated that employed hydrogels have regulated the silver nanoparticles size to 50–150 nm. The preliminary antibacterial activity performed to these hydrogel–silver nanocomposites.

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Figures

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Figure 1

Synthesis and chemical structure of cross-linked P(NIPAAm-MAA-HEM)

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Figure 2

FT-IR spectrum of cross-linked P(NIPAM-MAA-HEM) hydrogel

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Figure 3

1 H NMR spectrum of cross-linked P(NIPAAm-MAA-HEM) copolymer

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Figure 4

Typical cloud point measurements of cross-linked P(NIPAAm-MAA-HEM) hydrogel in distilled water

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Figure 5

Visual observation of macroscopic phase separation of aqueous solution of cross-linked P(NIPAAm-MAA-HEM)-1 hydrogel

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Figure 6

Equilibrium swelling ratios of the conventional PNIPAAm and cross-linked hydrogels over the temperature range of 21–45°C

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Figure 7

UV–Vis absorption spectra of silver nanoparticles as a function of NaBH4 concentration

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Figure 8

SEM image of CHSNC networks

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Figure 9

Antimicrobial activity of the purified CHSNC-1 against Acinetobacter (a) and P. aeruginosa (b) at 10 mg/ml concentration

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