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Research Paper

Heterostructured IrO2/Au Nanowire Electrodes and Unit Recordings From Hippocampal Rat Brain

[+] Author and Article Information
Hargsoon Yoon

Department of Engineering, Neural Engineering Laboratory, Norfolk State University, 700 Park Avenue, Norfolk, VA 23504

Phillip Hankins, Sechang Oh

Department of Electrical Engineering, Innovative Nano/Bio Devices and Systems Laboratory, University of Arkansas, 700 Research Center Boulevard, Fayetteville, AR 72701

Robert E. Harbaugh

Department of Neurosurgery, College of Medicine, Pennsylvania State Hershey Medical Center, 500 University Drive, Hershey, PA 17033

Vijay K. Varadan

Department of Electrical Engineering, Innovative Nano/Bio Devices and Systems Laboratory, University of Arkansas, 700 Research Center Boulevard, Fayetteville, AR 72701; Department of Neurosurgery, College of Medicine, Pennsylvania State Hershey Medical Center, 500 University Drive, Hershey, PA 17033

J. Nanotechnol. Eng. Med 1(2), 021006 (May 05, 2010) (4 pages) doi:10.1115/1.4001539 History: Received March 12, 2010; Revised March 31, 2010; Published May 05, 2010; Online May 05, 2010

This research presents the development of neural recording electrodes with high sensitivity using nanotechnology and the evaluation of their electrochemical sensing properties. Neural electrodes with heterostructured IrO2/Au nanowires have been fabricated on a flexible needle probe using a polyimide substrate. The outer, functional layer of the nanoelectrodes was made with a thin iridium oxide layer on vertically aligned Au nanowire cores providing low impedance and high charge storage capacity, which can enhance neural sensing and stimulating efficiency. Acute recording from the hippocampus of a rat brain has confirmed the neural sensing functionality of the heterostructured nanowire electrodes.

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Copyright © 2010 by American Society of Mechanical Engineers
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Figures

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Figure 1

SEM images: (a) microelectrode array with Au nanowires and (b) magnified image of Au nanowires

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Figure 2

SEM images: (a) needle probe with a microelectrode array, and ((b)–(d)) magnified images of the nanowire electrodes

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Figure 3

Electrochemical analysis on EIROF nanowire electrodes using (a) impedance spectroscopy and (b) charge storage capacity

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Figure 4

Neural spike recording from the hippocampus of a rat brain using IrO2/Au nanowire electrodes

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