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Research Papers

Development of an Oral Curcumin Nanocrystal Formulation

[+] Author and Article Information
R. Ravichandran

Regional Institute of Education (NCERT),
Mysore 570006, India
e-mail: ravincert@gmail.com

Manuscript received August 8, 2012; final manuscript received February 25, 2013; published online April 16, 2013. Assoc. Editor: Roger Narayan.

J. Nanotechnol. Eng. Med 3(4), 041007 (Apr 16, 2013) (7 pages) doi:10.1115/1.4023947 History: Received August 08, 2012; Revised February 25, 2013

During the last ten years, the formulation of drugs as nanocrystals has rapidly evolved into a mature drug delivery strategy, with currently five products on the market. The major characteristic of these systems is the rapid dissolution velocity, enabling bioavailability enhancement after oral administration. This study describes the preparation of a solid dosage capsule form of spray-dried curcumin nanocrystal and compares its dissolution behavior with market capsule in different media. The aim was to obtain a stable nanocrystal loaded drug capsule with an increased drug saturation solubility and dissolution velocity. The solubility and dissolution experiments were performed to verify the obvious improvement of the dissolution behavior compared with commercial product. Improved dissolution behavior in drug nanocrystal-loaded solid dosage forms should lead to better bioavailability of poorly soluble drugs in the body.

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Copyright © 2013 by ASME
Topics: Nanocrystals , Drugs
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Figures

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Fig. 1

Chemical structure of curcumin: (1E,6E)-1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; molecular formula C21H20O6; molar mass 368.38 g/mol; melting point 183 °C (361 K); and exhibit keto-enol tautomerism and the enol form is more energetically stable in the solid phase and in solution ∼95%

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Fig. 2

(a) Ordinary suspension and (b) the nanosuspension of curcumin

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Fig. 3

(a) PCS and (b) LD particles size distribution of curcumin formulations

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Fig. 4

Curcumin nanocrystal-loaded capsules (a) and marketed capsules (b)

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Fig. 5

Projected health benefits of Cur-500

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Fig. 6

Percentage of dissolved curcumin from nanocrystal-loaded capsules (formulation A) compared to microcrystal-loaded capsules (formulation B) in water (a); buffer at pH 1.2 (b), and pH 6.8 (c)

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Fig. 7

Percentage of dissolved curcumin from nanocrystals-loaded capsule in comparison with marketed capsule in water (a); buffer at pH 1.2 (b), and pH 6.8 (c)

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Fig. 8

Transfer of microcrystals to nanocrystals leads to an increase in surface area (upper). Increase in saturation solubility cs, decrease in diffusional distance h and increase in the concentration gradient cs − cx/h. All effects increase the dissolution velocity dc/dt.

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Fig. 9

Mechanism of action: finely dispersed nanocrystals versus aggregated nanocrystals

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