Chemical and biological detection systems have a broad range of applications, including monitoring of pollutants in the environment, assuring the safety of drinking water, and performing clinical analyses. Applications of particular interest to the military include detection of toxic compounds in water, military specific compounds in the environment, chemical and biological warfare agents, and explosives. Ideally, sample analysis can be performed in the field with lightweight, rugged, and reliable detection systems usable by personnel with minimal training. Fieldable analytical systems provide the user with a rapid response so that appropriate action can be taken to mitigate threats to the environment or to human health. Furthermore, on-site analysis reduces sample degradation or alteration and decreases costs associated with sample handling, laboratory infrastructure, and delayed response to deleterious events. Present research efforts are driven by the large gap between what is needed and what is currently available. LoaC or micrototal analysis systems (μTAS) systems possess the attributes needed to move many analytical methods to the field where rapid results are needed, sample degradation may occur during transport, for sampling when in austere environments, or when on-site sampling is simply less expensive. LoaC systems provide a platform on which the many parts of a complete sample analysis can be integrated, producing sensitive and selective sensors [1,2]. For example, sample preparation, separation, and detection have been integrated onto a single chip [3-6]. In addition, LoaC systems are inherently small, making it possible to create portable and lightweight analytical systems.