Nanocatalysts are adapted in this research to remove as the toxic, corrosive, and pyrophoric contaminant. The important feature which is considered is to enhance the adsorption efficiency of hydrogen sulfide from hydrocarbon fuels such as methane gas by applying the zinc oxide nanocatalyst. In general, the optimum conditions to eliminate the hydrogen sulfide from methane gas are evaluated in this paper, experimentally. In this study, zinc oxide nanoparticles are synthesized and are contacted with flow of sour methane. The synthesized nanoparticles are characterized by SEM. The process performance of removal from methane gas on zinc oxide nanoparticles is illustrated by the ratio of outlet concentration per feed concentration. The effects of operating conditions such as operating temperature, pressure, the occupied volume of bed, the amount of concentration in feed stream, feed superficial velocity, size of nanocatalyst, and the bed height are studied in this paper. Also, the cost estimations are presented for different operating pressures and temperatures. This work studies the adsorption of from natural gas with an emphasis on the influence of the operating parameters on process efficiency and cost evaluation. Finally, results introduce the amount of pressure 15 atm, temperature 300 °C, bed height 70 cm, and 35 nm in diameter nano zinc oxide as the optimum properties. Therefore, the amount of is decreased to 0.022. In addition, this is confirmed that the increase in the feed concentration of and feed superficial velocity, also the decrease in the diameter of zinc oxide catalyst enhances the process efficiency.