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Research Papers

Design and Fabrication of a Microfluidic Device for Synthesis of Chitosan Nanoparticles

[+] Author and Article Information
Barbaros Cetin

Microfluidics & Lab-on-a-chip Research Group,
Mechanical Engineering Department,
İhsan Dog̃ramacı Bilkent University,
Ankara 06800, Turkey
e-mail: barbaros.cetin@bilkent.edu.tr

Mehmet D. Asik

Nanotechnology and Nanomedicine Division,
Hacettepe University,
Ankara 06800, Turkey
e-mail: mehmetdoganasik@gmail.com

Serdar Taze

Microfluidics & Lab-on-a-chip Research Group,
Mechanical Engineering Department,
İhsan Dog̃ramacı Bilkent University,
Ankara 06800, Turkey
e-mail: serdar.taze@bilkent.edu.tr

1Corresponding author.

Manuscript received November 25, 2013; final manuscript received December 6, 2013; published online January 29, 2014. Assoc. Editor: Sushanta K Mitra.

J. Nanotechnol. Eng. Med 4(3), 031004 (Jan 29, 2014) (6 pages) Paper No: NANO-13-1083; doi: 10.1115/1.4026287 History: Received November 25, 2013; Revised December 06, 2013

Chitosan nanoparticles have a biodegradable, biocompatible, nontoxic structure, and are commonly used for drug delivery systems. In this study, design, modeling, and fabrication methodology of a microfluidic device for the synthesis of chitosan nanoparticles is presented. In the modeling, 2D flow and concentration field is computed using COMSOL Multiphysics® simulation environment to predict the performance of the device. The microfluidic chip is fabricated out of PDMS. The fabrication of the mold for the microfluidic device is performed using high-precision micromachining. Some preliminary proof-of-concept experiments were performed. It was observed that compared to conventional batch-type methods, the proposed microfluidic device can perform the synthesis much faster and in a much automated and convenient manner.

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References

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Figures

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Fig. 1

Drawing of the microfluidic device

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Fig. 2

Concentration field

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Fig. 3

Concentration profile at the exit

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Fig. 4

CAD drawing of the mold

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Fig. 5

Photograph of the mold

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Fig. 6

(a) Photograph of the microfluidic device and (b) photograph of the experimental setup

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Fig. 7

Result from the zeta sizer

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Fig. 8

AFM image of the nanoparticles

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