The separation method for a specific class of solid–liquid mixture depends on various factors such as the size of the particles, type/class of the liquid, mass/volume fraction of the particles in the mixture, physical properties of the base liquid and the particles. Filtration, distillation, centrifugation, electrophoresis, magnetic separation, chromatography, and chemical methods are among the most widely used methods to separate particulate matter from liquid–solid mixture. Every separation method has various operating requirements and the most critical ones being physical, chemical, and electrical properties of entities to be separated and the mixture to be processed [11-16]. By studying and analyzing such properties of NEPCM, various methods for the nanoparticle separation from the NEPCM have been identified. The identified methods include: (i) distillation under atmospheric and reduced pressure, (ii) mixing with alcohol mixture solvent, (iii) high speed centrifugation, (iv) chemical destabilization of nanoparticle surfactants to facilitate gravitational precipitation, (v) silica column chromatography, and (vi) adsorption on silica particle surfaces. These different nanoparticle separation methods have been pursued, tested, and evaluated. The results for the first three methods, which can be classified as physical separation methods, are presented in an earlier article . The next three methods, viz., chemical destabilization of nanoparticle surfactants, silica column chromatography, and adsorption on silica particle surface are chemical separation methods. The results for these three methods are analyzed and presented in this paper.