0
Research Papers

Experimental and Numerical Evaluation of Small-Scale Cryosurgery Using Ultrafine Cryoprobe

[+] Author and Article Information
Junnosuke Okajima

Institute of Fluid Science,
Tohoku University,
2-1-1 Katahira, Aoba-ku,
Sendai, Miyagi 980-8577, Japan
e-mail: okajima@pixy.ifs.tohoku.ac.jp

Atsuki Komiya

Institute of Fluid Science,
Tohoku University,
2-1-1 Katahira, Aoba-ku,
Sendai, Miyagi 980-8577, Japan
e-mail: komy@pixy.ifs.tohoku.ac.jp

Shigenao Maruyama

Institute of Fluid Science,
Tohoku University,
2-1-1 Katahira, Aoba-ku,
Sendai, Miyagi 980-8577, Japan
e-mail: maruyama@ifs.tohoku.ac.jp

1Corresponding author.

Manuscript received February 14, 2014; final manuscript received July 3, 2014; published online July 24, 2014. Assoc. Editor: Calvin Li.

J. Nanotechnol. Eng. Med 4(4), 040906 (Jul 24, 2014) (5 pages) Paper No: NANO-14-1011; doi: 10.1115/1.4027988 History: Received February 14, 2014; Revised July 03, 2014

The objective of this work is to experimentally and numerically evaluate small-scale cryosurgery using an ultrafine cryoprobe. The outer diameter (OD) of the cryoprobe was 550 μm. The cooling performance of the cryoprobe was tested with a freezing experiment using hydrogel at 37 °C. As a result of 1 min of cooling, the surface temperature of the cryoprobe reached −35 °C and the radius of the frozen region was 2 mm. To evaluate the temperature distribution, a numerical simulation was conducted. The temperature distribution in the frozen region and the heat transfer coefficient was discussed.

FIGURES IN THIS ARTICLE
<>
Copyright © 2013 by ASME
Your Session has timed out. Please sign back in to continue.

References

Bischof, J., Christov, K., and Rubinsky, B., 1993, “A Morphological-Study of Cooling Rate Response in Normal and Neoplastic Human Liver-Tissue-Cryosurgical Implications,” Cryobiology, 30(5), pp. 482–492. [CrossRef] [PubMed]
Popken, F., Seifert, J. K., Engelmann, R., Dutkowski, P., Nassir, F., and Junginger, T., 2000, “Comparison of Iceball Diameter and Temperature Distribution Achieved With 3-Mm Accuprobe Cryoprobes in Porcine and Human Liver Tissue and Human Colorectal Liver Metastases in Vitro,” Cryobiology, 40(4), pp. 302–310. [CrossRef] [PubMed]
Coleman, R. B., and Richardson, R. N., 2005, “A Novel Closed Cycle Cryosurgical System,” Int. J. Refrig., 28(3), pp. 412–418. [CrossRef]
Forest, V., Peoc'h, M., Campos, L., Guyotat, D., and Vergnon, J.-M., 2006, “Benefit of a Combined Treatment of Cryotherapy and Chemotherapy on Tumour Growth and Late Cryo-Induced Angiogenesis in a Non-Small-Cell Lung Cancer Model,” Lung Cancer, 54(1), pp. 79–86. [CrossRef] [PubMed]
Fredrickson, K., Nellis, G., and Klein, S., 2006, “A Design Method for Mixed Gas Joule–Thomson Refrigeration Cryosurgical Probes,” Int. J. Refrig., 29(5), pp. 700–715. [CrossRef]
Hewitt, P. M., Zhao, J., Akhter, J., and Morris, D. L., 1997, “A Comparative Laboratory Study of Liquid Nitrogen and Argon Gas Cryosurgery Systems,” Cryobiology, 35(4), pp. 303–308. [CrossRef] [PubMed]
Seifert, J. K., Gerharz, C. D., Mattes, F., Nassir, F., Fachinger, K., Beil, C., and Junginger, T., 2003, “A Pig Model of Hepatic Cryotherapy. In Vivo Temperature Distribution During Freezing and Histopathological Changes,” Cryobiology, 47(3), pp. 214–226. [CrossRef] [PubMed]
Rewcastle, J. C., Sandison, G. A., Saliken, J. C., Donnelly, B. J., and McKinnon, J. G., 1999, “Considerations During Clinical Operation of Two Commercially Available Cryomachines,” J. Surg. Oncol., 71(2), pp. 106–111. [CrossRef] [PubMed]
Popken, F., Land, M., Bosse, M., Erberich, H., Meschede, P., Konig, D. P., Fischer, J. H., and Eysel, P., 2003, “Cryosurgery in Long Bones With New Miniature Cryoprobe: An Experimental in Vivo Study of the Cryosurgical Temperature Field in Sheep,” Eur. J. Surg. Oncol., 29(6), pp. 542–547. [CrossRef] [PubMed]
Tacke, J., Adam, G., Haage, P., Sellhaus, B., Großkortenhaus, S., and Günther, R. W., 2001, “MR-Guided Percutaneous Cryotherapy of the Liver: In Vivo Evaluation With Histologic Correlation in an Animal Model,” J. Magn. Reson. Imaging, 13(1), pp. 50–56. [CrossRef] [PubMed]
Doll, N., Meyer, R., Walther, T., and Mohr, F. W., 2004, “A New Cryoprobe for Intraoperative Ablation of Atrial Fibrillation,” Ann. Thorac. Surg., 77(4), pp. 1460–1462. [CrossRef] [PubMed]
Takeda, H., Maruyama, S., Okajima, J., Aiba, S., and Komiya, A., 2009, “Development and Estimation of a Novel Cryoprobe Utilizing the Peltier Effect for Precise and Safe Cryosurgery,” Cryobiology, 59(3), pp. 275–284. [CrossRef] [PubMed]
Aihara, T., Kim, J.-K., Suzuki, K., and Kasahara, K., 1993, “Boiling Heat Transfer of a Micro-Impinging Jet of Liquid Nitrogen in a Very Slender Cryoprobe,” Int. J. Heat Mass Transfer, 36(1), pp. 169–175. [CrossRef]
Maruyama, S., Nakagawa, K., Takeda, H., Aiba, S., and Komiya, A., 2008, “The Flexible Cryoprobe Using Peltier Effect for Heat Transfer Control,” J. Biomech. Sci. Eng., 3(2), pp. 138–150. [CrossRef]
Bénita, M., and Condé, H., 1972, “Effects of Local Cooling Upon Conduction and Synaptic Transmission,” Brain Res., 36(1), pp. 133–151. [CrossRef] [PubMed]
Zhang, J.-X., Ni, H., and Harper, R. M., 1986, “A Miniaturized Cryoprobe for Functional Neuronal Blockade in Freely Moving Animals,” J. Neurosci. Methods, 16(1), pp. 79–87. [CrossRef] [PubMed]
Okajima, J., Komiya, A., and Maruyama, S., 2010, “Boiling Heat Transfer in Small Channel for Development of Ultrafine Cryoprobe,” Int. J. Heat Fluid Flow, 31(6), pp. 1012–1018. [CrossRef]
Okajima, J., Maruyama, S., Takeda, H., Komiya, A., and Sangkwon, J., 2010, “Cooling Characteristics of Ultrafine Cryoprobe Utilizing Convective Boiling Heat Transfer in Microchannel,” Proceedings of the 14th IHTC, Washington DC, Aug. 8–13, Vol. 1, pp. 297–306.
Voller, V. R., and Swaminathan, C. R., 1993, “Treatment of Discontinuous Thermal Conductivity in Control-Volume Solutions of Phase-Change Problems,” Numer. Heat Transfer, Part B, 24(2), pp. 161–180. [CrossRef]
Swaminathan, C. R., and Voller, V. R., 1992, “A General Enthalpy Method for Modeling Solidification Processes,” MTB, 23(5), pp. 651–664. [CrossRef]
Okajima, J., Takeda, H., Komiya, A., and Maruyama, S., 2008, “Possibility of Micro-Cryosurgery Utilizing Cooling Needle,” Proceedings of 16th International Conference on Mechanics in Medicine and Biology, Pittsburgh, PA, July 23–25.
Deng, Z.-S., and Liu, J., 2005, “Numerical Simulation of Selective Freezing of Target Biological Tissues Following Injection of Solutions With Specific Thermal Properties,” Cryobiology, 50(2), pp. 183–192. [CrossRef] [PubMed]
Gage, A. A., and Baust, J., 1998, “Mechanisms of Tissue Injury in Cryosurgery,” Cryobiology, 37(3), pp. 171–186. [CrossRef] [PubMed]

Figures

Grahic Jump Location
Fig. 6

Time variation of the frozen region at surface of the hydrogel

Grahic Jump Location
Fig. 7

Snapshots of the frozen region at 30 s obtained by (a) experiment and (b) calculation

Grahic Jump Location
Fig. 8

Temperature distribution around the ultrafine cryoprobe at 30 s

Grahic Jump Location
Fig. 5

Time variation of the surface temperature on the ultrafine cryoprobe

Grahic Jump Location
Fig. 4

Calculation domain

Grahic Jump Location
Fig. 3

Relationship between temperature and enthalpy for pure water

Grahic Jump Location
Fig. 2

Schematic of the experimental system

Grahic Jump Location
Fig. 1

Concept of the ultrafine cryoprobe

Grahic Jump Location
Fig. 9

Time variation of the heat flux on the ultrafine cryoprobe positioned at the surface of the hydrogel

Grahic Jump Location
Fig. 10

Time variation of local heat transfer coefficient for the refrigerant flow in the ultrafine cryoprobe positioned at the surface of the hydrogel

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In