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Research Papers

On Centrioles, Microtubules, and Cellular Electromagnetism

[+] Author and Article Information
Ronald L. Huston

Life Fellow ASME
Department of Mechanical
and Materials Engineering,
University of Cincinnati,
P.O. Box 210072,
Cincinnati, OH 45221-0072
e-mail: ron.huston@uc.edu

Manuscript received August 18, 2014; final manuscript received October 13, 2014; published online November 11, 2014. Assoc. Editor: Feng Xu.

J. Nanotechnol. Eng. Med 5(3), 031003 (Aug 01, 2014) (5 pages) Paper No: NANO-14-1054; doi: 10.1115/1.4028855 History: Received August 18, 2014; Revised October 13, 2014; Online November 11, 2014

This paper describes the inner workings of centrioles (a pair of small organelles adjacent to the nucleus) as they create cell electropolarity, engage in cell division (mitosis), but in going awry, also promote the development of cancers. The electropolarity arises from vibrations of microtubules composing the centrioles. Mitosis begins as each centrioles duplicates itself by growing a daughter centriole on its side. If during duplication more than one daughter is grown, cancer can occur and the cells divide uncontrollably. Cancer cells with supernumerary centrioles have high electropolarity which can serve as an attractor for charged therapeutic nanoparticles.

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Figures

Grahic Jump Location
Fig. 5

Duplicated centrioles (two pairs)

Grahic Jump Location
Fig. 3

MT blades of a centriole

Grahic Jump Location
Fig. 1

Cross section of a typical eukaryotic (animal/human) cell

Grahic Jump Location
Fig. 7

Two daughter centrioles from one mother centriole

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