0
Research Papers

Synthesis of Zn-Doped Manganese Ferrite Nanoparticles Via Coprecipitation Method for Magnetic Resonance Imaging Contrast Agent

[+] Author and Article Information
Firooz Salehpour

Professor
Department of Neurosurgery,
Tabriz University of Medical Sciences,
Tabriz, Iran
e-mail: firoozsalehpour@hotmail.com

Ainaz Khorramdin

Department of Material Sciences
and Engineering,
Shiraz University of Technology,
Shiraz, Iran
e-mail: a.khorramdin@sutech.ac.ir

Hooman Shokrollahi

Assistant Professor
Department of Material Sciences
and Engineering,
Shiraz University of Technology,
Shiraz, Iran
e-mail: shokrollahi@sutech.ac.ir

Arastoo Pezeshki

Department of Material Sciences
and Engineering,
Shiraz University of Technology,
Shiraz, Iran
e-mail: Draraspz@yahoo.com

Farhad Mirzaei

Department of Neurosurgery,
Tabriz University of Medical Sciences,
Tabriz, Iran

Nader D. Nader

Professor
Department of Anesthesiology,
University at Buffalo
252 Farber Hall,
South Campus,
Buffalo, NY 14214
e-mail: nnader@buffalo.edu

1Corresponding author.

Manuscript received August 1, 2014; final manuscript received February 13, 2015; published online March 11, 2015. Assoc. Editor: Roger Narayan.

J. Nanotechnol. Eng. Med 5(4), 041002 (Nov 01, 2014) (6 pages) Paper No: NANO-14-1052; doi: 10.1115/1.4029855 History: Received August 01, 2014; Revised February 13, 2015; Online March 11, 2015

Two different preparations of biocompatible magnetic nanoparticles (MNPs), both (MnFe2O4 and Mn0.91Zn0.09Fe2O4) coated with methoxy polyethylene glycol aldehyde (m-PEG-CHO) were prepared through coprecipitation method. The prepared powder was reanalyzed for material structure with an X-ray diffractometer (XRD) and for particle size using a transition electron microscope (TEM). Magnetic saturation (MS) and coercivity (HC) of the formed particles were examined by a vibrating sample magnetometer (VSM). Surface structure of the samples was characterized by Fourier transform infrared spectroscopy (FTIR). Biocompatible ferrofluids were intravenously injected into four rabbits. Then the magnetic resonance (MR) images of brain were obtained by magnetic resonance imaging (MRI) experiments before and after intravenous injection of ferrofluids. The MNPs demonstrate super paramagnetic behavior with a spinel structure measuring 30–40 nm in size. Doping of these magnetite nanoparticles with zinc resulted in decreases in crystallite size from 24.23 nm to 21.15 nm, the lattice parameter from 8.45 Å to 8.43 Å and the coercivity from 41.20 Oe to 13.07 Oe. On the other hand, saturation magnetization increased from 50.12 emu/g to 57.36 emu/g following zinc doping. Image exposure analysis revealed that the reduction of MR signal intensity for zinc-doped magnetite nanoparticles was more than nondoped nanoparticles (shorter T2 relaxation time) thereby making the images darker.

FIGURES IN THIS ARTICLE
<>
Copyright © 2014 by ASME
Your Session has timed out. Please sign back in to continue.

References

Ghazanfar, U., Siddiqi, S. A., and Abbas, G., 2005, “Study of Room Temperature DC Resistivity in Comparison With Activation Energy and Drift Mobility of NiZn Ferrites,” Mater. Sci. Eng.: B, 118(1–3), pp. 132–134. [CrossRef]
Snoek, J. L., 1947, New Developments in Ferromagnetic Materials, Elsevier, New York.
Sugimoto, M., 1999, “The Past, Present, and Future of Ferrites,” J. Am. Ceram. Soc., 82(2), pp. 269–280. [CrossRef]
Hu, P., Yang, H., Pan, D., Wang, H., Tian, J., Zhang, S., Wang, X., and Volinsky, A. A., 2010, “Heat Treatment Effects on Microstructure and Magnetic Properties of Mn–Zn Ferrite Powders,” J Magn. Magn. Mater., 322(1), pp. 173–177. [CrossRef]
Parveen, S., Misra, R., and Sahoo, S. K., 2012, “Nanoparticles: A Boon to Drug Delivery, Therapeutics, Diagnostics and Imaging,” Nanomed.: Nanotechnol., Biol., Med., 8(2), pp. 147–166. [CrossRef]
Neel, L., 1948, “Magnetic Properties of Femtes: Ferrimagnetism and Antiferromagnetism,” Ann. Phys. Paris, 3, pp. 137–198.
Waqas, H., and Qureshi, A. H., 2009, “Influence of pH on Nanosized Mn–Zn Ferrite Synthesized by Sol–Gel Auto Combustion Process,” J. Therm. Anal. Calorim., 98(2), pp. 355–360. [CrossRef]
Rao, A. D. P., Ramesh, B., Rao, P. R. M., and Raju, S. B., 1999, “Magnetic and Microstructural Properties of Sn/Nb Substituted Mn–Zn Ferrites,” J. Alloys Compd., 282(1), pp. 268–273. [CrossRef]
Wang, J., Su, M. Y., Qi, J. Q., and Chang, L. Q., 2009, “Sensitivity and Complex Impedance of Nanometer Zirconia Thick Film Humidity Sensors,” Sens. Actuators B, 139(2), pp. 418–424. [CrossRef]
Chang, L. Q., Liu, C., He, Y., Xiao, H., and Cai, X., 2011, “Small-Volume Solution Current-Time Behavior Study for Application in Reverse Iontophoresis-Based Non-Invasive Blood Glucose Monitoring,” Sci. China-Chem., 54(1), pp. 223–230. [CrossRef]
Humaira, A., and Asghari, M., 2010, “Temperature Dependent Structural and Electrical Analysis of Mn–Zn Nano Ferrites,” J. Pak. Mat. Soc., 4(2), pp. 81–94.
Kondo, A., and Fukuda, H., 1997, “Preparation of Thermo-Sensitive Magnetic Hydrogel Microspheres and Application to Enzyme Immobilization,” J. Ferment. Bioeng., 84(4), pp. 337–341. [CrossRef]
Šepelák, V., Heitjans, P., and Becker, K. D., 2007, “Nanoscale Spinel Ferrites Prepared by Mechanochemical Route,” J. Therm. Anal. Calorim., 90(1), pp. 93–97. [CrossRef]
Thomsen, H. S., Morcos, S. K., and Dawson, P., 2006, “Is There a Causal Relation Between the Administration of Gadolinium Based Contrast Media and the Development of Nephrogenic Systemic Fibrosis (NSF)?,” Clin. Radiol., 61(11), pp. 905–906. [CrossRef] [PubMed]
Elgavish, G. A., Brown, R. D., Miller, S. K., Spiller, M., Koenig, S. H., and Pohost, G. M., 1987, “A New Category of High-Relaxivity Contrast Agents Enables Nmr Imaging of Infarcted Myocardium at Low Agent Dosage,” Circulation, 76(4), pp. 159–159.
Bonnemain, B., 1998, “Superparamagnetic Agents in Magnetic Resonance Imaging: Physicochemical Characteristics and Clinical Applications—A Review,” J. Drug Target, 6(3), pp. 167–174. [CrossRef] [PubMed]
Hofmann-Amtenbrink, M., Hofmann, H., and Montet, X., 2010, “Superparamagnetic Nanoparticles—A Tool for Early Diagnostics,” Swiss Med. Wkly., 140, pp. 7–13.
Hong, R. Y., Feng, B., Chen, L. L., Liu, G. H., Li, H. Z., Zheng, Y., and Wei, D. G., 2008, “Synthesis, Characterization and MRI Application of Dextran-Coated Fe3O4 Magnetic Nanoparticles,” Biochem. Eng. J., 42(3), pp. 290–300. [CrossRef]
Stark, D. D., Weissleder, R., Elizondo, G., Hahn, P. F., Saini, S., Todd, L. E., Wittenberg, J., and Ferrucci, J. T., 1988, “Superparamagnetic Iron-Oxide—Clinical-Application as a Contrast Agent for MR Imaging of the Liver,” Radiology, 168(2), pp. 297–301. [CrossRef] [PubMed]
Hung, C. W., Holoman, T. R. P., Kofinas, P., and Bentley, W. E., 2008, “Towards Oriented Assembly of Proteins Onto Magnetic Nanoparticles,” Biochem. Eng. J., 38(2), pp. 164–170. [CrossRef]
Yao, Z., Zhang, C., Ping, Q. N., and Yu, L. L. L., 2007, “A Series of Novel Chitosan Derivatives: Synthesis, Characterization and Micellar Solubilization of Paclitaxel,” Carbohydr. Polym., 68(4), pp. 781–792. [CrossRef]
Mahato, R. I., 2005, Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids, CRC Press, Boca Raton, FL. [CrossRef]
Kohler, N., Fryxell, G. E., and Zhang, M. Q., 2004, “A Bifunctional Poly(Ethylene Glycol) Silane Immobilized on Metallic Oxide-Based Nanoparticles for Conjugation With Cell Targeting Agents,” J. Am. Chem. Soc., 126(23), pp. 7206–7211. [CrossRef] [PubMed]
Arulmurugana, R., Jeyadevanb, B., Vaidyanathana, G., and Sendhilnathanc, S., 2005, “Effect of Zinc Substitution on Co–Zn and Mn–Zn Ferrite Nanoparticles Prepared by Co-Precipitation,” J. Magn. Magn. Mat., 288, pp. 470–477. [CrossRef]
Elahi, I., Zahira, R., Mehmood, K., Jamil, A., and Amin, N., 2012, “Co-Precipitation Synthesis, Physical and Magnetic Properties of Manganese Ferrite Powder,” Afr. J. Pure Appl. Chem., 6(1), pp. 1–5.
Feng, B., Honga, R. Y., Wanga, L. S., Guoc, L., Lib, H. Z., Dingd, J., Zhenge, Y., and Weif, D. G., 2008, “Synthesis of Fe3O4/APTES/PEG Diacid Functionalized Magnetic Nanoparticles for MR Imaging,” Colloids Surf. A., 328(1–3), pp. 52–59. [CrossRef]
Fischer, G., Cao, X., Cox, N., and Francis, M., 2004, “The FT-IR Spectra of Glycine and Glycylglycine Zwitterions Isolated in Alkali Halide Matrices,” Chem. Phys., 313(1–3), pp. 39–49. [CrossRef]
Masoudi, A., Madaah Hosseini, H. R., Shokrgozar, M. A., Ahmadi, R., and Oghabian, M. A., 2012, “The Effect of Poly(Ethylene Glycol) Coating on Colloidal Stability of Superparamagnetic Iron Oxide Nanoparticles as Potential MRI Contrast Agent,” Int. J. Pharm., 433(1–2), pp. 129–141. [CrossRef] [PubMed]
Sun, C. R., Du, K., Fang, C., Bhattarai, N., Veiseh, O., Kievit, F., Stephen, Z., Lee, D. H., Ellenbogen, R. G., Ratner, B., and Zhang, M. Q., 2010, “PEG-Mediated Synthesis of Highly Dispersive Multifunctional Superparamagnetic Nanoparticles: Their Physicochemical Properties and Function in Vivo,” ACS Nano, 4(4), pp. 2402–2410. [CrossRef] [PubMed]
Sun, C., Sze, R., and Zhang, M. Q., 2006, “Folic Acid-PEG Conjugated Superparamagnetic Nanoparticles for Targeted Cellular Uptake and Detection by MRI,” J. Biomed. Mater. Res. A, 78(3), pp. 550–557. [CrossRef] [PubMed]
Veiseh, O., Gunn, J. W., Kievit, F. M., Sun, C., Fang, C., Lee, J. S. H., and Zhang, M. Q., 2009, “Inhibition of Tumor-Cell Invasion With Chlorotoxin-Bound Superparamagnetic Nanoparticles,” Small, 5(2), pp. 256–264. [CrossRef] [PubMed]
Sze, A., Erickson, D., Ren, L. Q., and Li, D. Q., 2003, “Zeta-Potential Measurement Using the Smoluchowski Equation and the Slope of the Current-Time Relationship in Electroosmotic Flow,” J. Colloid Interface Sci., 261(2), pp. 402–410. [CrossRef] [PubMed]
Zhang, Y. Q., Wei, X. W., and Yu, R., 2010, “Fe3O4 Nanoparticles-Supported Palladium-Bipyridine Complex: Effective Catalyst for Suzuki Coupling Reaction,” Catal. Lett., 135(3–4), pp. 256–262. [CrossRef]

Figures

Grahic Jump Location
Fig. 1

Preparation of nanoparticles: (a) aldehydization (m-PEG-CHO) and (b) polyethylene glycation processes

Grahic Jump Location
Fig. 2

X-Ray diffraction patterns recorded for MnFe2O4 MNPs (a) and Mn0.91Zn0.09Fe2O4 MNP (b) powders. Average particle size was calculated and reported using Scherrer's formula (Eq. (5)). Additionally, the average lattice parameter and distance were calculated with a precision of 0.01% using the Bragg equation (Eq. (6)).

Grahic Jump Location
Fig. 3

Transmission electron microscopy of Mn0.91Zn0.09Fe2O4 MNPs (a), m-PEG-coated Mn0.91Zn0.09Fe2O4 MNPs (b), MnFe2O4 MNPs (c), and MnFe2O4 m-PEG-coated MNPs (d). The range both for coated and uncoated MNPs was 30–40 nm.

Grahic Jump Location
Fig. 4

The heating ratios (transmittance percentage) were measured over the range of infrared spectrum. The figure shows the FTIR spectra for Mn0.91Zn0.09Fe2O4-m-PEG-coated (a); MnFe2O4-m-PEG-coated (b); MNPs; Mn0.91Zn0.09Fe2O4 (c); MnFe2O4 (d); MNPs and PEG core by itself (e)

Grahic Jump Location
Fig. 5

Magnetization curves measured Ms = 57.36 emu/g for Mn0.91Zn0.09Fe2O4 MNPs (a); Ms = 28.32 emu/g for m-PEG-coated-Mn0.91Zn0.09Fe2O4 MNPs (b); Ms = 50.12 emu/g for MnFe2O4 MNPs (c); and Ms = 19.21 emu/g for m-PEG-coated-MnFe2O4 MNPs (d)

Grahic Jump Location
Fig. 6

Magnetic resonance signals intensity of rabbit brain in T2-weighted sequences before (a and c) and 1 hr after intravenous injection of m-PEG-coated-Mn0.91Zn0.09Fe2O4 suspension (b) and m-PEG-coated-MnFe2O4 suspension (d). For full details, please refer to the text.

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In