Research Papers

Synthesis of Zn-Doped Manganese Ferrite Nanoparticles Via Coprecipitation Method for Magnetic Resonance Imaging Contrast Agent

[+] Author and Article Information
Firooz Salehpour

Department of Neurosurgery,
Tabriz University of Medical Sciences,
Tabriz, Iran
e-mail: firoozsalehpour@hotmail.com

Ainaz Khorramdin

Department of Material Sciences
and Engineering,
Shiraz University of Technology,
Shiraz, Iran
e-mail: a.khorramdin@sutech.ac.ir

Hooman Shokrollahi

Assistant Professor
Department of Material Sciences
and Engineering,
Shiraz University of Technology,
Shiraz, Iran
e-mail: shokrollahi@sutech.ac.ir

Arastoo Pezeshki

Department of Material Sciences
and Engineering,
Shiraz University of Technology,
Shiraz, Iran
e-mail: Draraspz@yahoo.com

Farhad Mirzaei

Department of Neurosurgery,
Tabriz University of Medical Sciences,
Tabriz, Iran

Nader D. Nader

Department of Anesthesiology,
University at Buffalo
252 Farber Hall,
South Campus,
Buffalo, NY 14214
e-mail: nnader@buffalo.edu

1Corresponding author.

Manuscript received August 1, 2014; final manuscript received February 13, 2015; published online March 11, 2015. Assoc. Editor: Roger Narayan.

J. Nanotechnol. Eng. Med 5(4), 041002 (Nov 01, 2014) (6 pages) Paper No: NANO-14-1052; doi: 10.1115/1.4029855 History: Received August 01, 2014; Revised February 13, 2015; Online March 11, 2015

Two different preparations of biocompatible magnetic nanoparticles (MNPs), both (MnFe2O4 and Mn0.91Zn0.09Fe2O4) coated with methoxy polyethylene glycol aldehyde (m-PEG-CHO) were prepared through coprecipitation method. The prepared powder was reanalyzed for material structure with an X-ray diffractometer (XRD) and for particle size using a transition electron microscope (TEM). Magnetic saturation (MS) and coercivity (HC) of the formed particles were examined by a vibrating sample magnetometer (VSM). Surface structure of the samples was characterized by Fourier transform infrared spectroscopy (FTIR). Biocompatible ferrofluids were intravenously injected into four rabbits. Then the magnetic resonance (MR) images of brain were obtained by magnetic resonance imaging (MRI) experiments before and after intravenous injection of ferrofluids. The MNPs demonstrate super paramagnetic behavior with a spinel structure measuring 30–40 nm in size. Doping of these magnetite nanoparticles with zinc resulted in decreases in crystallite size from 24.23 nm to 21.15 nm, the lattice parameter from 8.45 Å to 8.43 Å and the coercivity from 41.20 Oe to 13.07 Oe. On the other hand, saturation magnetization increased from 50.12 emu/g to 57.36 emu/g following zinc doping. Image exposure analysis revealed that the reduction of MR signal intensity for zinc-doped magnetite nanoparticles was more than nondoped nanoparticles (shorter T2 relaxation time) thereby making the images darker.

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Grahic Jump Location
Fig. 1

Preparation of nanoparticles: (a) aldehydization (m-PEG-CHO) and (b) polyethylene glycation processes

Grahic Jump Location
Fig. 2

X-Ray diffraction patterns recorded for MnFe2O4 MNPs (a) and Mn0.91Zn0.09Fe2O4 MNP (b) powders. Average particle size was calculated and reported using Scherrer's formula (Eq. (5)). Additionally, the average lattice parameter and distance were calculated with a precision of 0.01% using the Bragg equation (Eq. (6)).

Grahic Jump Location
Fig. 3

Transmission electron microscopy of Mn0.91Zn0.09Fe2O4 MNPs (a), m-PEG-coated Mn0.91Zn0.09Fe2O4 MNPs (b), MnFe2O4 MNPs (c), and MnFe2O4 m-PEG-coated MNPs (d). The range both for coated and uncoated MNPs was 30–40 nm.

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Fig. 4

The heating ratios (transmittance percentage) were measured over the range of infrared spectrum. The figure shows the FTIR spectra for Mn0.91Zn0.09Fe2O4-m-PEG-coated (a); MnFe2O4-m-PEG-coated (b); MNPs; Mn0.91Zn0.09Fe2O4 (c); MnFe2O4 (d); MNPs and PEG core by itself (e)

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Fig. 5

Magnetization curves measured Ms = 57.36 emu/g for Mn0.91Zn0.09Fe2O4 MNPs (a); Ms = 28.32 emu/g for m-PEG-coated-Mn0.91Zn0.09Fe2O4 MNPs (b); Ms = 50.12 emu/g for MnFe2O4 MNPs (c); and Ms = 19.21 emu/g for m-PEG-coated-MnFe2O4 MNPs (d)

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Fig. 6

Magnetic resonance signals intensity of rabbit brain in T2-weighted sequences before (a and c) and 1 hr after intravenous injection of m-PEG-coated-Mn0.91Zn0.09Fe2O4 suspension (b) and m-PEG-coated-MnFe2O4 suspension (d). For full details, please refer to the text.




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