Research Papers

Visualization and Motion of Curcumin Loaded Iron Oxide Nanoparticles During Magnetic Drug Targeting

[+] Author and Article Information
Mohammed Asfer

Department of Mechanical Engineering,
IIT Kanpur,
Kanpur 208016, India
e-mail: asfer786@gmail.com

Ayodhya Prasad Prajapati

Department of Mechanical Engineering,
IIT Kanpur,
Kanpur 208016, India
e-mail: ayodhya1989@gmail.com

Arun Kumar

School of Mechanical Engineering,
Sastra University,
Thanjavur 613401, Tamil Nadu, India
e-mail: arunmct04@gmail.com

Pradipta Kumar Panigrahi

Department of Mechanical Engineering,
IIT Kanpur,
Kanpur 208016, India
e-mail: panig@iitk.ac.in

1Corresponding author.

Manuscript received May 13, 2015; final manuscript received July 4, 2015; published online July 28, 2015. Assoc. Editor: Abraham Quan Wang.

J. Nanotechnol. Eng. Med 6(1), 011004 (Jul 28, 2015) (8 pages) Paper No: NANO-15-1041; doi: 10.1115/1.4031062 History: Received May 13, 2015

Magnetic drug targeting (MDT) involves the localization of drug loaded iron oxide nanoparticles (IONPs) around the malignant tissue using external magnetic field for therapeutic purposes. The present in vitro study reports the visualization and motion of curcumin loaded IONPs (CU-IONPs) around the target site inside a microcapillary (500 × 500 μm2 square cross section), in the presence of an externally applied magnetic field. Application of magnetic field leads to transportation and aggregation of CU-IONPs toward the target site inside the capillary adjacent to the magnet. The localization/aggregation of CU-IONPs at the target site shows strong dependence on the strength of the applied magnetic field and flow rate of ferrofluid through the capillary. Such an in vitro study offers a viable for optimization and design of MDT systems for in vivo applications.

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Ahmed, N. , Fessi, H. , and Elaissari, A. , 2012, “Theranostic Applications of Nanoparticles in Cancer,” Drug Discovery Today, 17(17–18), pp. 928–934. [CrossRef] [PubMed]
Etgar, L. , Nakhmani, A. , Tannenbaum, A. , Lifshitz, E. , and Tannenbaum, R. , 2010, “Trajectory Control of PbSe-Gamma-Fe2O3 Nanoplatforms Under Viscous Flow and an External Magnetic Field,” Nanotechnology, 21(17), p. 175702. [CrossRef] [PubMed]
Lim, J. , Lanni, C. , Evarts, E. R. , Lanni, F. , Tilton, R. D. , and Majetich, S. A. , 2011, “Magnetophoresis of Nanoparticles,” ACS Nano, 5(1), pp. 217–226. [CrossRef] [PubMed]
Widder, K. J. , Morris, R. M. , Poore, G. , Howard, D. P., Jr. , and Senyei, A. E. , 1981, “Tumor Remission in Yoshida Sarcoma-Bearing Rats by Selective Targeting of Magnetic Albumin Microspheres Containing Doxorubicin,” Proc. Natl. Acad. Sci. U. S. A., 78(1), pp. 579–581. [CrossRef] [PubMed]
Goodwin, S. , Peterson, C. , Hoh, C. , and Bittner, C. , 1999, “Targeting and Retention of Magnetic Targeted Carriers (MTCs) Enhancing Intra-Arterial Chemotherapy,” J. Magn. Magn. Mater., 194(1), pp. 132–139. [CrossRef]
Voltairas, P. A. , Fotiadis, D. I. , and Michalis, L. K. , 2002, “Hydrodynamics of Magnetic Drug Targeting,” J. Biomech., 35(6), pp. 813–821. [CrossRef] [PubMed]
Grief, A. D. , and Richardson, G. , 2005, “Mathematical Modelling of Magnetically Targeted Drug Delivery,” J. Magn. Magn. Mater., 293(1), pp. 455–463. [CrossRef]
Jurgons, R. , Seliger, C. , Hilpert, A. , Trahms, L. , Odenbach, S. , and Alexiou, C. , 2006, “Drug Loaded Magnetic Nanoparticles for Cancer Therapy,” J. Phys.: Condens. Matter, 18(38), pp. S2893–S2902. [CrossRef]
Furlani, E. P. , and Ng, K. C. , 2006, “Analytical Model of Magnetic Nanoparticle Transport and Capture in the Microvasculature,” Phys. Rev. E, 73(6), p. 061919. [CrossRef]
Shaw, S. , Murthy, P. V. S. N. , and Pradhan, S. C. , 2010, “Effect of Non-Newtonian Characteristics of Blood on Magnetic Targeting in the Impermeable Micro-Vessel,” J. Magn. Magn. Mater., 322(8), pp. 1037–1043. [CrossRef]
Furlani, E. J. , and Furlani, E. P. , 2007, “A Model for Predicting Magnetic Targeting of Multifunctional Particles in the Microvasculature,” J. Magn. Magn. Mater., 312(1), pp. 187–193. [CrossRef]
Yang, J. , Park, J. , Lee, J. , Cha, B. , Song, Y. , Yoon, H. G. , Huh, Y. M. , and Haam, S. , 2007, “Motions of Magnetic Nanosphere Under the Magnetic Field in the Rectangular Microchannel,” J. Magn. Magn. Mater., 317(1–2), pp. 34–40. [CrossRef]
Anwar, M. , Asfer, M. , Prajapati, A. P. , Mohapatra, S. , Akhter, S. , Ali, A. , and Ahmad, F. J. , 2014, “Synthesis and In Vitro Localization Study of Curcumin-Loaded SPIONs in a Micro Capillary for Simulating a Targeted Drug Delivery System,” Int. J. Pharm., 468(1–2), pp. 158–164. [CrossRef] [PubMed]
Magnetic Drug Targeting in Cancer Therapy, http://www.comsol.com/
Mendelev, V. S. , and Ivanov, A. O. , 2004, “Ferrofluid Aggregation in Chains Under the Influence of a Magnetic Field,” Phys. Rev. E, 70(5), p. 051502. [CrossRef]
Kays, W. , and Crawford, M. , 1993, Convective Heat and Mass Transfer, McGraw-Hill, Inc., New York.
Walsh, P. A. , Egan, V. M. , and Walsh, E. J. , 2010, “Novel Micro-PIV Study Enables a Greater Understanding of Nanoparticle Suspension Flows: Nanofluids,” Microfluid. Nanofluid., 8(6), pp. 837–842. [CrossRef]
Zhu, T. , Lichlyter, D. J. , Haidekker, M. A. , and Mao, L. , 2011, “Analytical Model of Microfluidic Transport of Non-Magnetic Particles in Ferrofluids Under the Influence of a Permanent Magnet,” Microfluid. Nanofluid., 10(6), pp. 1233–1245. [CrossRef]


Grahic Jump Location
Fig. 1

Principle of localization of drug loaded IONPs at the target site during MDT

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Fig. 2

(a) TEM image of CU-IONPs, (b) particle size distribution of CU-IONPs, (c) fluorescence microscopic image of CU-IONPs, and (d) magnetization curve of ferrofluid and CU-IONPs

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Fig. 3

(a) Schematic of the experimental set up for MDT, (b) capillary-permanent magnet arrangement, and (c) capillary-electromagnet arrangement used during the MDT

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Fig. 4

(a) Schematic of the confocal microscopy system and (b) schematic of the μ-PIV system

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Fig. 10

μ-PIV images showing the localization of CU-IONPs at the wall of the capillary adjacent to the tip of the electromagnet at various time instants: (a) t = 0+s, (b) t = 100 s, (c) t = 200 s, and (d) t = 400 s, respectively. The flow rate of ferrofluid is set equal to Q = 20 μl/min through the capillary.

Grahic Jump Location
Fig. 9

(a) Processed vector map for ferrofluid flow in the absence of magnetic field at flow rate Q = 20 μl/min through the capillary and (b) the comparison of u -velocity profile with that from the analytical prediction for laminar flow through a rectangular microchannel (Eq. (2))

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Fig. 6

(a) Fluorescence and (b) bright field imaging of aggregate of CU-IONPs at the target site inside the capillary

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Fig. 5

Distribution of (a) magnetic flux density B, (b) magnetic force component fmx, and (c) magnetic force component fmy acting on the ferrofluid in the presence of magnetic field produced by the permanent magnet

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Fig. 11

Velocity vector fields for ferrofluid flow in the presence of magnetic field at different time instants: (a) t = 0 +s, (b) t = 100 s, (c) t = 200 s, and (d) t = 400 s, respectively. The ferrofluid flow rate is set at Q = 20 μl/min through the capillary.

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Fig. 8

Comparison of volume of aggregate of CU-IONPs at the target site versus time

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Fig. 7

Localization of CU-IONPs at the target site for different ferrofluid flow rates: (a) Q = 5 μl/min and (b) Q = 20 μl/min through the capillary



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