Nanostructured semiconductors with emerging optical or electronic properties have demonstrated wide-spread applications in microelectronics, optoelectronics [1-4], chemical [5,6] and biomolecular sensors [7-11], biomedical drug delivery , and biomolecular separation . Recently, nanostructured surfaces are further opening new opportunities in rare cell analysis and stem cell engineering via nanoscale cell–surface interactions. Silicon or quartz nanowire substrates functionalized with antibodies against cell surface antigens were reported for high-efficiency rare cell capture  and hold great potential for clinical applications such as counting circulating tumor cells for differential diagnosis of cancer progression and metastasis . Vertical silicon nanowires were exploited for physical delivery of genes or biomolecules into live cells . The effect of nanoscale surface topography on the motility and vitality of cells is a topic of increasing interest. Cellular response to nanoscale topography has been studied using a range of surface nanotopologies [17-22] and nanobiomaterials [18,23]. Studies have shown that nanoscale cellular structures, such as focal adhesion and integrin, interact with the underlying topography of the substrate, which in turn affects cell behavior such as morphology, cell adhesion, cell spreading, motility, gene expression, and differentiation [19,22,24,25]. Nanotopography, with the feature size comparable to the functional cell adhesion structures, plays a unique role in regulating cell–surface interaction and subsequently mediating survival, proliferation, and differentiation of stem cells [26-31].