0
Expert View

Scaffold-Based or Scaffold-Free Bioprinting: Competing or Complementing Approaches?

[+] Author and Article Information
Ibrahim T. Ozbolat

Professor
Biomanufacturing Laboratory,
The University of Iowa,
Iowa City, IA 52242
e-mail: ibrahim-ozbolat@uiowa.edu

Manuscript received April 12, 2015; final manuscript received April 16, 2015; published online September 29, 2015. Assoc. Editor: Abraham Quan Wang.

J. Nanotechnol. Eng. Med 6(2), 024701 (Sep 29, 2015) Paper No: NANO-15-1034; doi: 10.1115/1.4030414 History: Received April 12, 2015

Bioprinting is an emerging technology to fabricate artificial tissues and organs through additive manufacturing of living cells in a tissues-specific pattern by stacking them layer by layer. Two major approaches have been proposed in the literature: bioprinting cells in a scaffold matrix to support cell proliferation and growth, and bioprinting cells without using a scaffold structure. Despite great progress, particularly in scaffold-based approaches along with recent significant attempts, printing large-scale tissues and organs is still elusive. This paper demonstrates recent significant attempts in scaffold-based and scaffold-free tissue printing approaches, discusses the advantages and limitations of both approaches, and presents a conceptual framework for bioprinting of scale-up tissue by complementing the benefits of these approaches.

FIGURES IN THIS ARTICLE
<>
Copyright © 2015 by ASME
Your Session has timed out. Please sign back in to continue.

References

Figures

Grahic Jump Location
Fig. 1

Scaffold-based and scaffold-free bioprinting technologies: (a) extrusion-based bioprinting, (b) droplet-based bioprinting, (c) laser-based bioprinting, (d) bioprinting tissue spheroids, and (e) bioprinting cell pellet

Grahic Jump Location
Fig. 2

Hybrid bioprinting of scaffold-based vascular constructs in tandem with scaffold-free parenchyma tissue, where fusion, tissue remodeling, and self-assembly of tissue strands take place and sprouting can take place between the macrovascular network and capillaries in tissue strands. This concept generalizes the tissue used; however, for different tissue types, modifications on the system would be essential.

Tables

Errata

Discussions

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging and repositioning the boxes below.

Related Journal Articles
Related eBook Content
Topic Collections

Sorry! You do not have access to this content. For assistance or to subscribe, please contact us:

  • TELEPHONE: 1-800-843-2763 (Toll-free in the USA)
  • EMAIL: asmedigitalcollection@asme.org
Sign In