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Research Papers

Visualization and Motion of Curcumin Loaded Iron Oxide Nanoparticles During Magnetic Drug Targeting

[+] Author and Article Information
Mohammed Asfer

Department of Mechanical Engineering,
IIT Kanpur,
Kanpur 208016, India
e-mail: asfer786@gmail.com

Ayodhya Prasad Prajapati

Department of Mechanical Engineering,
IIT Kanpur,
Kanpur 208016, India
e-mail: ayodhya1989@gmail.com

Arun Kumar

School of Mechanical Engineering,
Sastra University,
Thanjavur 613401, Tamil Nadu, India
e-mail: arunmct04@gmail.com

Pradipta Kumar Panigrahi

Department of Mechanical Engineering,
IIT Kanpur,
Kanpur 208016, India
e-mail: panig@iitk.ac.in

1Corresponding author.

Manuscript received May 13, 2015; final manuscript received July 4, 2015; published online July 28, 2015. Assoc. Editor: Abraham Quan Wang.

J. Nanotechnol. Eng. Med 6(1), 011004 (Jul 28, 2015) (8 pages) Paper No: NANO-15-1041; doi: 10.1115/1.4031062 History: Received May 13, 2015

Magnetic drug targeting (MDT) involves the localization of drug loaded iron oxide nanoparticles (IONPs) around the malignant tissue using external magnetic field for therapeutic purposes. The present in vitro study reports the visualization and motion of curcumin loaded IONPs (CU-IONPs) around the target site inside a microcapillary (500 × 500 μm2 square cross section), in the presence of an externally applied magnetic field. Application of magnetic field leads to transportation and aggregation of CU-IONPs toward the target site inside the capillary adjacent to the magnet. The localization/aggregation of CU-IONPs at the target site shows strong dependence on the strength of the applied magnetic field and flow rate of ferrofluid through the capillary. Such an in vitro study offers a viable for optimization and design of MDT systems for in vivo applications.

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Figures

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Fig. 1

Principle of localization of drug loaded IONPs at the target site during MDT

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Fig. 2

(a) TEM image of CU-IONPs, (b) particle size distribution of CU-IONPs, (c) fluorescence microscopic image of CU-IONPs, and (d) magnetization curve of ferrofluid and CU-IONPs

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Fig. 3

(a) Schematic of the experimental set up for MDT, (b) capillary-permanent magnet arrangement, and (c) capillary-electromagnet arrangement used during the MDT

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Fig. 4

(a) Schematic of the confocal microscopy system and (b) schematic of the μ-PIV system

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Fig. 5

Distribution of (a) magnetic flux density B, (b) magnetic force component fmx, and (c) magnetic force component fmy acting on the ferrofluid in the presence of magnetic field produced by the permanent magnet

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Fig. 6

(a) Fluorescence and (b) bright field imaging of aggregate of CU-IONPs at the target site inside the capillary

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Fig. 7

Localization of CU-IONPs at the target site for different ferrofluid flow rates: (a) Q = 5 μl/min and (b) Q = 20 μl/min through the capillary

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Fig. 8

Comparison of volume of aggregate of CU-IONPs at the target site versus time

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Fig. 9

(a) Processed vector map for ferrofluid flow in the absence of magnetic field at flow rate Q = 20 μl/min through the capillary and (b) the comparison of u -velocity profile with that from the analytical prediction for laminar flow through a rectangular microchannel (Eq. (2))

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Fig. 10

μ-PIV images showing the localization of CU-IONPs at the wall of the capillary adjacent to the tip of the electromagnet at various time instants: (a) t = 0+s, (b) t = 100 s, (c) t = 200 s, and (d) t = 400 s, respectively. The flow rate of ferrofluid is set equal to Q = 20 μl/min through the capillary.

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Fig. 11

Velocity vector fields for ferrofluid flow in the presence of magnetic field at different time instants: (a) t = 0 +s, (b) t = 100 s, (c) t = 200 s, and (d) t = 400 s, respectively. The ferrofluid flow rate is set at Q = 20 μl/min through the capillary.

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