It is well known that pore design is an important determinant of both the quantity and distribution of regenerated bone in artificial bone tissue scaffolds. A requisite feature is that scaffolds must contain pore interconnections on the order of 100–1000 (termed macroporosity). Within this range, there is not a definitive optimal interconnection size. Recent results suggest that pore interconnections permeating the scaffold build material on the order of 2–20 (termed microporosity) drive bone growth into the macropore space at a faster rate and also provide a new space for bone growth, proliferating throughout the interconnected microporous network. The effects of microstructural features on bone growth has yet to be fully understood. This work presents the manufacture and characterization of novel combinatorial test scaffolds, scaffolds that test multiple microporosity and macroporosity designs within a single scaffold. Scaffolds such as this can efficiently evaluate multiple mechanical designs, with the advantage of having the designs colocated within a single defect site and therefore less susceptible to experimental variation. This paper provides the manufacturing platform, manufacturing control method, and demonstrates the manufacturing capabilities with three representative scaffolds.
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e-mail: hoelzle2@illinois.edu
e-mail: sviente1@illinois.edu
e-mail: alleyne@illinois.edu
e-mail: ajwj@illinois.edu
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October 2011
Research Papers
Design and Manufacture of Combinatorial Calcium Phosphate Bone Scaffolds
David J. Hoelzle,
David J. Hoelzle
Department of Mechanical Science and Engineering,
e-mail: hoelzle2@illinois.edu
University of Illinois at Urbana-Champaign
, Urbana, IL 61801
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Shelby R. Svientek,
Shelby R. Svientek
Department of Bioengineering,
e-mail: sviente1@illinois.edu
University of Illinois at Urbana-Champaign
, Urbana, IL 61801
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Andrew G. Alleyne,
Andrew G. Alleyne
Department of Mechanical Science and Engineering,
e-mail: alleyne@illinois.edu
University of Illinois at Urbana-Champaign
, Urbana, IL 61801
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Amy J. Wagoner Johnson
Amy J. Wagoner Johnson
Department of Mechanical Science and Engineering,
e-mail: ajwj@illinois.edu
University of Illinois at Urbana-Champaign
, Urbana, IL 61801
Search for other works by this author on:
David J. Hoelzle
Department of Mechanical Science and Engineering,
University of Illinois at Urbana-Champaign
, Urbana, IL 61801e-mail: hoelzle2@illinois.edu
Shelby R. Svientek
Department of Bioengineering,
University of Illinois at Urbana-Champaign
, Urbana, IL 61801e-mail: sviente1@illinois.edu
Andrew G. Alleyne
Department of Mechanical Science and Engineering,
University of Illinois at Urbana-Champaign
, Urbana, IL 61801e-mail: alleyne@illinois.edu
Amy J. Wagoner Johnson
Department of Mechanical Science and Engineering,
University of Illinois at Urbana-Champaign
, Urbana, IL 61801e-mail: ajwj@illinois.edu
J Biomech Eng. Oct 2011, 133(10): 101001 (8 pages)
Published Online: October 27, 2011
Article history
Received:
May 21, 2011
Revised:
September 9, 2011
Accepted:
September 9, 2011
Online:
October 27, 2011
Published:
October 27, 2011
Citation
Hoelzle, D. J., Svientek, S. R., Alleyne, A. G., and Wagoner Johnson, A. J. (October 27, 2011). "Design and Manufacture of Combinatorial Calcium Phosphate Bone Scaffolds." ASME. J Biomech Eng. October 2011; 133(10): 101001. https://doi.org/10.1115/1.4005173
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