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Journal Articles

Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber

Shahab Azimi, Siamak Arzanpour
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. April 2024, 146(4): 041002.
Paper No: BIO-23-1276
https://doi.org/10.1115/1.4064436
Published Online: February 7, 2024
View Article titled, Enhancing Inhalation Drug Delivery: A Comparative Study and Design Optimization of a Novel Valved Holding Chamber
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Topics: Design, Optimization, Particulate matter, Simulation, Valves, Drugs, Engineering prototypes, Flow (Dynamics), Drug delivery systems
Journal Articles

Subcutaneous Drug Delivery: A Review of the State-of-the-Art Modeling and Experimental Techniques

Paramveer Sharma, Kishore Gajula, Naga Neehar Dingari, Rakesh Gupta, Sharath Gopal, Beena Rai, Ronald G. Iacocca
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Review Articles
J Biomech Eng. February 2023, 145(2): 020801.
Paper No: BIO-22-1148
https://doi.org/10.1115/1.4055758
Published Online: October 11, 2022
View Article titled, Subcutaneous Drug Delivery: A Review of the State-of-the-Art Modeling and Experimental Techniques
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Topics: Biological tissues, Drug delivery systems, Modeling, Needles, Skin, Deformation, Stress, Anisotropy, Damage
Journal Articles

Using Parallel Coordinates in Optimization of Nano-Particle Drug Delivery

Timoleon Kipouros, Ibrahim Chamseddine, Michael Kokkolaras
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. April 2022, 144(4): 044501.
Paper No: BIO-21-1174
https://doi.org/10.1115/1.4052578
Published Online: November 5, 2021
View Article titled, Using Parallel Coordinates in Optimization of Nano-Particle Drug Delivery
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Topics: Design, Drug delivery systems, Nanoparticles, Optimization, Tumors, Modeling, Drugs
Journal Articles

Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study

Adithya Gurumurthy, Clement Kleinstreuer
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2021, 143(11): 111001.
Paper No: BIO-21-1035
https://doi.org/10.1115/1.4051217
Published Online: July 14, 2021
View Article titled, Improving Pulmonary Nanotherapeutics Using Helical Aerosol Streams: An In Silico Study
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Topics: Aerosols, Drugs, Flow (Dynamics), Nanoparticles, Particulate matter, Lung, Diffusion (Physics), Fluids, Drug delivery systems
Journal Articles

A MEMS-Based Drug Delivery Device With Integrated Microneedle Array—Design and Simulation

Farshid Meshkinfam, Ghus Rizvi
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. August 2021, 143(8): 081010.
Paper No: BIO-20-1536
https://doi.org/10.1115/1.4050754
Published Online: May 4, 2021
View Article titled, A MEMS-Based Drug Delivery Device With Integrated Microneedle Array—Design and Simulation
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Topics: Design, Diaphragms (Mechanical devices), Diaphragms (Structural), Dimensions, Drug delivery systems, Flow (Dynamics), Fluids, Microelectromechanical systems, Microneedles, Micropumps
Journal Articles

Enhanced Targeted Drug Delivery Through Controlled Release in a Three-Dimensional Vascular Tree

Shuang J. Zhu, Eric K. W. Poon, Andrew S. H. Ooi, Stephen Moore
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. March 2015, 137(3): 031002.
Paper No: BIO-13-1410
https://doi.org/10.1115/1.4028965
Published Online: March 1, 2015
View Article titled, Enhanced Targeted Drug Delivery Through Controlled Release in a Three-Dimensional Vascular Tree
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Topics: Drugs, Particulate matter, Simulation, Flow (Dynamics), Drug delivery systems, Algorithms, Modeling
Journal Articles

Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery

Xiaoxiang Zhu, Richard D. Braatz
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. November 2014, 136(11): 111004.
Paper No: BIO-14-1169
https://doi.org/10.1115/1.4028135
Published Online: September 4, 2014
View Article titled, Modeling and Analysis of Drug-Eluting Stents With Biodegradable PLGA Coating: Consequences on Intravascular Drug Delivery
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Topics: Coating processes, Coatings, Drugs, PLGA, Stents, Struts (Engineering), Drug delivery systems
Journal Articles

Experimental and Numerical Models of Three-Dimensional Gravity-Driven Flow of Shear-Thinning Polymer Solutions Used in Vaginal Delivery of Microbicides

Vitaly O. Kheyfets, Sarah L. Kieweg
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research-Article
J Biomech Eng. June 2013, 135(6): 061009.
Paper No: BIO-12-1580
https://doi.org/10.1115/1.4024140
Published Online: May 9, 2013
View Article titled, Experimental and Numerical Models of Three-Dimensional Gravity-Driven Flow of Shear-Thinning Polymer Solutions Used in Vaginal Delivery of Microbicides
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Topics: Computer simulation, Flow (Dynamics), Fluids, Gravity (Force), Sensitivity analysis, Shear (Mechanics), Simulation, Shapes, Drug delivery systems, Surface tension
Journal Articles

Experimental Techniques for Studying Poroelasticity in Brain Phantom Gels Under High Flow Microinfusion

O. Ivanchenko, N. Sindhwani, A. Linninger
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. May 2010, 132(5): 051008.
https://doi.org/10.1115/1.4001164
Published Online: March 29, 2010
View Article titled, Experimental Techniques for Studying Poroelasticity in Brain Phantom Gels Under High Flow Microinfusion
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Topics: Biological tissues, Brain, Catheters, Deformation, Displacement, Flow (Dynamics), Fluids, Hydraulic conductivity, Polariscopes, Porosity
Journal Articles

Peptide- and Aptamer-Functionalized Nanovectors for Targeted Delivery of Therapeutics

Todd O. Pangburn, Matthew A. Petersen, Brett Waybrant, Maroof M. Adil, Efrosini Kokkoli
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technology Review
J Biomech Eng. July 2009, 131(7): 074005.
https://doi.org/10.1115/1.3160763
Published Online: July 31, 2009
View Article titled, Peptide- and Aptamer-Functionalized Nanovectors for Targeted Delivery of Therapeutics
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Topics: Cancer, DNA, Drug delivery systems, Drugs, Nanoparticles, Proteins, Tumors, Vehicles, Patient treatment
Journal Articles

Freezing-Assisted Intracellular Drug Delivery to Multidrug Resistant Cancer Cells

Ka Yaw Teo, Bumsoo Han
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Briefs
J Biomech Eng. July 2009, 131(7): 074513.
https://doi.org/10.1115/1.3153325
Published Online: June 29, 2009
View Article titled, Freezing-Assisted Intracellular Drug Delivery to Multidrug Resistant Cancer Cells
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Topics: Cancer, Drug delivery systems, Drugs, Freezing, Proteins, Fluorescence, Membranes, Cell membranes, Microscopy
Journal Articles

Three-Dimensional Computational Modeling of Subject-Specific Cerebrospinal Fluid Flow in the Subarachnoid Space

Sumeet Gupta, Michaela Soellinger, Peter Boesiger, Dimos Poulikakos, Vartan Kurtcuoglu
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. February 2009, 131(2): 021010.
https://doi.org/10.1115/1.3005171
Published Online: December 10, 2008
View Article titled, Three-Dimensional Computational Modeling of Subject-Specific Cerebrospinal Fluid Flow in the Subarachnoid Space
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Topics: Cerebrospinal fluid, Computational fluid dynamics, Flow (Dynamics), Magnetic resonance imaging, Porous materials, Pressure, Brain, Drug delivery systems, Permeability, Cardiac cycle
Journal Articles

Effect of Blood Flow on Near-the-Wall Mass Transport of Drugs and Other Bioactive Agents: A Simple Formula to Estimate Boundary Layer Concentrations

Sandra Rugonyi
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Research Papers
J Biomech Eng. April 2008, 130(2): 021010.
https://doi.org/10.1115/1.2899571
Published Online: March 28, 2008
View Article titled, Effect of Blood Flow on Near-the-Wall Mass Transport of Drugs and Other Bioactive Agents: A Simple Formula to Estimate Boundary Layer Concentrations
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Topics: Boundary layers, Drugs, Blood, Blood flow, Finite element model, Diffusion (Physics), Flow (Dynamics), Drug delivery systems, Blood vessels
Journal Articles

Squeezing Flows of Vaginal Gel Formulations Relevant to Microbicide Drug Delivery

Sarah L. Kieweg, David F. Katz
Journal: Journal of Biomechanical Engineering
Publisher: ASME
Article Type: Technical Papers
J Biomech Eng. August 2006, 128(4): 540–553.
https://doi.org/10.1115/1.2206198
Published Online: February 1, 2006
View Article titled, Squeezing Flows of Vaginal Gel Formulations Relevant to Microbicide Drug Delivery
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Topics: Flow (Dynamics), Rheology, Drug delivery systems, Yield stress