Abstract
A fatal methocarbamol intoxication is presented. Significant toxicologic findings were blood concentrations of 525 mg/L methocarbamol and 140 mg/dL ethanol. Analysis was by thin-layer, gas-liquid, and high pressure liquid chromatography. Toxicology data relevant to the interpretation of case findings are discussed.
References
1.
Huff
, B. B.
, Ed., Physicians' Desk Reference
, 34th ed., Medical Economics Co.
, Orandell, NJ
, 1980
, p. 1436.2.
Registry of Human Toxicology
, American Academy of Forensic Sciences, Toxicology Section
, Colorado Springs, CO
, 1978
.3.
Garriott
, J. C.
and Latman
, N.
, “Drug Detection in Cases of 'Driving Under the Influence,'
” Journal of Forensic Sciences.
, Vol. 21
, No. 2
, 04
1976
, pp. 398
–415
.4.
Frings
, C. S.
, “Colorimetric Methods for the Quantitative Determination of Acetaminophen in Serum
,” Clinical Toxicology
, Vol. 15
, No. 1
, 01
1979
, pp. 67
–73
.5.
Trinder
, P.
, “Rapid Determination of salicylate in Biological Fluids
,” Biochemical Journal.
, Vol. 57
, 1954
, pp. 301
–303
.6.
Dubowski
, K. M.
, “Ethanol, Type C Procedure
,” in Methodology for Analytical Toxicology.
, 2nd ed., I.
Sunshine
, Ed., CRC Press
, Cleveland, OH
, 1975
, pp. 149
–154
.7.
Davidow
, B.
, Petri
, N. L.
, and Quame
, B.
, “A Thin Layer Chromatographic Procedure for Detecting Drug Abuse
,” American Journal of Clinical Pathology.
0002-9173, Vol. 50
, No. 6
, 12
1968
, pp. 714
–719
.8.
Zingales
, I.
, “Systemic Identification of Psychotropic Drugs by Thin Layer Chromatography. Part 1
,” Journal of Chromatography
, Vol. 31
, No. 2
, 12
1967
, pp. 405
–419
.9.
Kananen
, G.
, Osiewicz
, R.
, and Sunshine
, I.
, “Barbiturate Analysis—A Current Assessment
,” Journal of Chromatographic Science.
, Vol. 10
, No. 5
, 05
1972
, pp. 283
–287
.10.
Martis
, L.
and Levy
, R. H.
, “GLC Determination of Meprobamate in Water, Plasma and Urine
,” Journal of Pharmaceutical Sciences.
, Vol. 63
, No. 6
, 06
1974
, pp. 834
–837
.11.
Finkle
, B. S.
, “The Identification, Quantitative Determination, and Distribution of Meprobamate and Glutethimide in Biological Material
,” Journal of Forensic Sciences.
, Vol. 12
, No. 4
, 10
1967
, pp. 509
–528
.12.
Sprague
, K.
and Poklis
, A.
, “Determination of Barbiturates in Postmortem Blood by High Pressure Liquid Chromatography: A Comparison with a Differential Ultraviolet Spectrophotometric Method
,” Canadian Society of Forensic Science Journal
, Vol. 13
, No. 1
, 03
1980
, pp. 31
–36
.13.
Kabra
, P. M.
, Koo
, H. Y.
, and Marton
, L. J.
, “Simultaneous Liquid Chromatographic Determination of 12 Common Sedatives and Hypnotics in Serum
,” Clinical Chemistry.
, Vol. 24
, No. 4
, 04
1978
, pp. 657
–662
.14.
Huf
, E. G.
, Coles
, F. K.
, and Eabank
, L. L.
, “Comparative Plasma Levels of Mephenesin, Carbamate and Methocarbamol
,” Proceedings of the Society of Experimental Biology and Medicine
, Vol. 102
, 1959
, pp. 276
–277
.15.
Forist
, A. A.
and Judy
, R. W.
, “Comparative Pharmacokinetics of Chlorphenesin, Carbamate and Methocarbamol in Man
,” Journal of Pharmaceutical Science
, Vol. 60
, No. 11
, 11
1971
, pp. 1686
–1688
.16.
Williams
, L. A.
, “Salicylate (Salicylic Acid), Type B Procedures
,” in Methodology in Analytical Toxicology
, I.
Sunshine
, Ed., CRC Press
, Cleveland, OH
, 1971
, pp. 307
–308
.
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