Abstract

In order to use genetic loci in forensic identity testing, some population data are needed. This paper presents a report of allele frequency data for the loci HUMTH01, HUMTPOX and HUMVWA in a population sample from Northern Spain.

No deviation from the Hardy-Weinberg equilibrium was detected in any of the three markers investigated and there was no evidence of association between the alleles of these loci.

Statistical analysis was also carried out to obtain some parameters of medicolegal interest and comparative studies were carried out with other populations studied to date for these five loci. The Asturian sample does not differ substantially from other Caucasian and Spanish populations.

References

1.
Edwards
A
,
Civitello
A
,
Hammond
H A
,
Caskey
C T
.
DNA typing and genetic mapping with trimeric and tetrameric tandem repeats
.
Am J Hum Genet
1991
;
49
:
746
-
56
.
2.
Edwards
A
,
Hammond
H A
,
Jin
L
,
Caskey
C T
,
Chakraborty
R
.
Genetic variation at five trimeric and tetrameric repeat loci in four human population groups
.
Genomics
 0888-7543
1992
;
12
:
241
-
53
.
3.
Gené
M
,
Carracedo
A
,
Huguet
E
,
Pérez-Pérez
A
,
Moreno
P
.
Population genetics of the D12S391, CSF1P0 and TPOX loci in Catalonia (Northeast Spain)
.
Int J Legal Med
1998
;
111
:
52
-
4
.
4.
Gené
M
,
Huguet
E
,
Moreno
P
,
Sánchez
C
,
Corbella
J
,
Mezquita
J
.
Suitability of the HUMTH01, HUMCD4 and HUMVWA STR polymorphisms for Legal Medicine investigations in the population of Catalonia (North-East Spain)
. In:
Carracedo
A
,
Brinkmann
B
,
Bar
W
, editors.
Advances in Forensic Haemogenetics 6
.
Berlin, Heidelberg
,
Springer
,
1996
;
540
-
1
.
5.
Martínez Jarreta
B
,
Diaz Roche
P
,
Budowle
B
,
Abecia
E
,
Castellano
M
,
Casalod
Y
.
Pyrenean population data on three tetrameric short tandem repeat loci-HUMTH01, TPOX and CSF1PO derived using a STR multiplex system
. In:
Advances in Forensic Haemogenetics 7
. In press.
6.
Martín
P
,
Alonso
A
,
Budowle
B
,
Albarrán
C
,
García
O
,
Sancho
M
.
Spanish population data on seven tetrameric short tandem repeat loci
.
Int J Legal Med
1995
;
108
:
145
-
9
.
7.
Andres
M I
,
Prieto
V
,
Flores
I C
,
Sanz
P
.
Population genetics of three STRs: THO1, CSF1PO and TPOX in Southern Spain
. In:
Carracedo
A
,
Brinkmann
B
,
Bär
W
, editors.
Advances in Forensic Haemogenetics 6
.
Berlin, Heidelber
,
Springer
,
1996
;
489
-
91
.
8.
Iriondo
M
,
Barbero
M C
,
Izaguirre
N
,
Manzano
C
.
Data on six short tandem repeat polymorphisms in an autochthonous Basque population
.
Hum Heredity
1997
;
47
:
131
-
7
.
9.
Pestoni
C
,
Lareu
M V
,
Rodriguez
M S
,
Muñoz
I
,
Barros
F
,
Carracedo
A
.
The use of the STRs HUMTH01, HUMVWA31/A, HUMF13A1, HUMFES/FPS, HUMLPL in forensic application: validation studies and population data for Galicia (NW Spain)
.
Int J legal Med
1995
;
107
:
283
-
90
.
10.
Hochmeister
M N
,
Budowle
B
,
Schumm
J W
,
Sprecher
C J
,
Borer
U V
,
Dirnhofer
R
.
Swiss population data and forensic efficiency values on three tetrameric short tandem repeat loci HUMTH01, TPOX, and CSF1PO derived using STR multiplex system
.
Int J Leg Med
1995
;
107
:
246
-
9
.
11.
Kratzer
A
,
Bär
W
.
Swiss population data for the STR systems HUMVWA, HUMF13A1 and HUMFES
. In:
Carracedo
A
,
Brinkmann
B
,
Bär
W
, editors.
Advances in Forensic Haemogenetics 6
.
Berlin, Heidelberg
,
Springer
,
1996
;
563
-
8
.
12.
Prata
M J
,
Amorim
A
,
Gusmao
L
,
Trovoada
M J
.
Population genetics of the STRs TPOX, TH01 and VWFA31/A in S. Tomé e Príncipe
. In:
Carracedo
A
,
Brinkmann
B
,
Bär
W
, editors.
Advances in Forensic Haemogenetics 6
.
Berlin, Heidelberg
,
Springer
,
1996
;
604
-
6
.
13.
Nakamura
S
,
Sawaguchi
T
,
Sawaguchi
A
.
Forensic application of STR polymorphic markers
. In:
Carracedo
A
,
Brinkmann
B
,
Bär
W
, editors.
Advances in Forensic Haemogenetics 6
.
Berlin, Heidelberg
,
Springer
,
1996
;
589
-
91
.
14.
Martínez-Jarreta
B
,
Abecia
E
,
Bell
B
,
Casalod
Y
,
Castellano
M
,
Hinojal
R
.
Frequencies of the five PCR-based genetic markers LDLR, GYPA, D7S8, HBGG and Gc in the population of Asturias (North Spain)
.
Int J Legal Med
1997
;
110
:
41
-
3
.
15.
Anker
R
,
Steinbreuc
K T
,
Donnis-Keller
H
.
Tetranucleotide repeat polymorphism at the human thyroid peroxidase (hTPO) locus
.
Human Mol Genet
1992
;
1
:137.
16.
Kimpton
C
,
Walton
A
,
Gill
P
.
A further tetranucleotide repeat polymorphism in the VWF gene
.
Hum Mol Genet
1992
;
1
:287.
17.
DNA Recommendations-1992
.
Report concerning recommendations of the DNA Commission of the International Society for Forensic Haemogenetics relating to the use of PCR-based polymorphisms
.
Int J Legal Med
1992
;
105
:
63
-
4
.
18.
DNA recommendations-1994
.
Report concerning futher recommendations of the DNA Commission of the International Society for Forensic Haemogenetics regarding PCR-based polymorphisms in STR systems
.
Int J Legal Med
1994
;
107
:
159
-
60
.
19.
Bell
B
,
Budowle
B
,
Martínez-Jarreta
B
,
Casalod
Y
,
Abecia
E
,
Castellano
M
.
Distribution of types for six PCR-based loci: LDLR, GYPA, D7S8, HBGG, Gc and HLA-DQA1 in Central Pyrenees and Teruel (Spain)
.
J Forensic Sci
1997
;
42
(
3
):
510
-
3
.
20.
Budowle
B
,
Monson
K L
,
Chakraborty
R
.
Estimating minimum allele frequencies for DNA profile frequency estimates for PCR-based loci
.
Int J Legal Med
1996
;
108
:
173
-
6
.
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