Abstract
Three new color/screening tests for flunitrazepam (Rohypnol) are reported. The two-step tests are simple, sensitive, highly specific, and effective for both cut and uncut flunitrazepam and standard over-the-counter preparations of flunitrazepam (i.e., Rohypnol tablets.)
Issue Section:
Technical Notes
References
1.
Microgram
1992
;25
(3
):42.2.
Microgram
1993
;26
(4
):55.3.
Microgram
1994
;27
(12
):402.4.
Microgram
1995
;28
:177.5.
Microgram
1995
;28
(10
):315.6.
Microgram
1996
;29
(3
):56.7.
Microgram
1997
;30
(7
):136.8.
Tolliver
J M
, U.S. Drug Enforcement Administration, Office of Diversion Control, personal communication, 1998
.9.
Sternbach
R
, et al Quinazolines and 1,4-benzodiazepines. X. Nitrosubstituted 5-phenyl-1,4-benzodiazepine derivatives
. J Med Chem
1963
;6
:261.10.
The Merck Index
, 10th Ed., Rahway, NJ
, Merck and Co., Inc.
, 1983
;405111.
U.S. CFR 21:1308.14.
12.
Schutz
H
. Mikropreparation Wichtiger Flunitrazepam-Metaboliten durch Reaktion auf der Dunnschichtplatte
. J Chromatogr
1979
;168
:429
-34
.13.
Schutz
H
. Benzodiazepines a handbook basic data, analytical methods, pharmacokinetics and comprehensive literature, 21–23, 171, 186, 377
Berlin, Germany
, Springer-Verlag
, 1982
.14.
Analytical profiles of the benzodiazepines
. Auburn, AL
, CND Analytical
, 1989
;56
-59
.15.
Rochholz
G
, Ahrens
B
, Schuetz
H
. Modified screening procedure with fluorescence detection for flunitrazepam
. Arzneimittel Forschung
1994
;44
:467
-71
.16.
Rucker
C L
. Chemical screening and identification techniques for flunitrazepam
. Microgram
1998
(in press).17.
Riddick
J A
, Bunger
W B
. Organic solvents. II
. New York
, Wiley-Interscience
, 1970
.18.
Szwarc
M
, Ions and ion pairs in organic reactions
. 2
. New York
, John Wiley & Sons
, 1974
.
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