Abstract

We describe the application of histochemical demonstration of chromium in a case of fatal ingestion of potassium dichromate in a suicide attempt. Using 2-(8-quinolylazo)-4,5-di-p-tolylimidazole (QTI), we could demonstrate chromium in the erythrocyte of the victim, in situ. This finding provides a means of proving the hexavalent chromium ingestion.

References

1.
Ellenhorn
MJ
,
Barceloux
DG
.
Dichromate
. In:
Ellenhorn
MJ
,
Barceloux
DG
, editors.
Medical toxicology diagnosis and treatment of human poisoning
.
New York
:
Elsevier
1988
;
1020
2
.
2.
Michie
CA
,
Hayhurst
M
,
Knobel
GJ
,
Stokol
JM
,
Hensley
B
.
Poisoning with a traditional remedy containing potassium dichromate
.
Hum Exp Toxicol
 0960-3271
1991
;
10
:
129
31
.
3.
Barceloux
DG
.
Chromium
.
J Toxicol Clin Toxicol
 0731-3810
1999
;
37
:
173
94
.
4.
Pascale
LR
,
Waldstein
S
,
Engbring
G
,
Dubin
A
.
Chromium intoxication with special reference to hepatic injury
.
JAMA
 0098-7484
1952
;
149
:
1385
9
.
5.
Kaufman
DB
,
DiNicola
W
,
McIntosh
R
.
Acute potassium dichromate poisoning treated by peritoneal dialysis
.
Amer J Dis Child
1970
;
119
:
374
6
.
6.
Sumi
Y
,
Itoh
MT
,
Yoshida
M
,
Suzuki
T
.
Histochemical staining of chromium with 2-(8-quinolylazo)-4,5-di-p-tolylimidazole
.
Eur J Histochem
 0391-7258
1998
;
42
:
271
6
.
7.
Tanaka
T
,
Nose
T
,
Hayashi
Y
,
Sugiyama
K
,
Funakawa
K
,
Ishizawa
M
.
Concentration of chromium in biological materials (blood, serum, urine and scarp hair) from the chromium mine workers
.
Medicine and Biology
 0302-2137
1980
;
101
:
277
81
.
8.
Kinoshita
H
,
Koizumi
M
,
Ijiri
I
,
Ameno
S
,
Seki
K
,
Kumihashi
M
, et al
.
A fatal case due to potassium dichromate ingestion
.
Jpn J Toxicol
2000
;
13
:
407
9
.
9.
Sumi
Y
,
Muraki
T
,
Suzuki
T
.
The choice of a masking agent in the histochemical staining of metals
.
Histochem J
 0018-2214
1983
;
15
:
231
8
.
10.
Sumi
Y
,
Muraki
T
,
Suzuki
T
.
Histochemical staining of cadmium with benzothiazolylazonaphthol derivatives
.
Histochemistry
 0301-5564
1982
;
73
:
481
6
.
11.
Gray
SJ
,
Sterling
K
.
The tagging of red cells and plasma proteins with radioactive chromium
.
J Clin Invest
 0021-9738
1950
;
29
:
1604
13
.
12.
Pearson
HA
,
Vertrees
KM
.
Site of binding of chromium 51 to haemoglobin
.
Nature
 0028-0836
1961
;
189
:
1019
20
.
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