The object of the study was to fill and coat the microcavities of a drug eluting stent using a batch dipping process. 316L coronary stents, which were coated with a layer of were used as substrates. The stents’ surface was dimpled with microcavities separated by distances of depending on location. The experiment consisted of (1) optimizing the procedures to fill the microcavities with a solution of therapeutic agent and (2) covering the filled microcavities with a protective “lid” that shielded the solution during stent insertion in the arteries and then controlled its release into the surrounding tissue. The filling solution was a water-propanol mix containing 20% L-arginine. The coating solution was comprised of poly-ethylene-glycol (PEG-8000) and dexamethasone. The filling quality was investigated after altering the following variables: plasma surface activation (type of gas, pressure, power, and duration), water-propanol percentage ratio of the filling solution, lifting speed from the bath, and effect of ultrasonic vibration (monofrequency versus multifrequency). The surface coating was evaluated by altering the PEG-8000-dexamethasone percentage ratio and recording the effects on coating thickness and structure, on elution rate, and on wear resistance. The optimized process is presented in detail.
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March 2009
Research Papers
Optimization of Plasma Treatment, Manipulative Variables and Coating Composition for the Controlled Filling and Coating of a Microstructured Reservoir Stent
Mustapha Mekki,
Mustapha Mekki
Research Scientist
Hexacath
, 92508 Paris, France
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Stéphane Durual,
Stéphane Durual
Research Scientist
Laboratory of Biomaterials,
University of Geneva
, 19 rue Barthélemy-Menn, 1205 Geneva, Switzerland
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Susanne S. Scherrer,
Susanne S. Scherrer
Research Scientist
Laboratory of Biomaterials,
University of Geneva
, 19 rue Barthélemy-Menn, 1205 Geneva, Switzerland
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Johannes Lammers,
Johannes Lammers
Consultant
1006 Lausanne, Switzerland
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H. W. Anselm Wiskott
H. W. Anselm Wiskott
Research Scientist
Laboratory of Biomaterials, School of Dentistry,
e-mail: anselm@wiskott.com
University of Geneva
, 19 rue Barthélemy-Menn, 1205 Geneva, Switzerland
Search for other works by this author on:
Mustapha Mekki
Research Scientist
Hexacath
, 92508 Paris, France
Stéphane Durual
Research Scientist
Laboratory of Biomaterials,
University of Geneva
, 19 rue Barthélemy-Menn, 1205 Geneva, Switzerland
Susanne S. Scherrer
Research Scientist
Laboratory of Biomaterials,
University of Geneva
, 19 rue Barthélemy-Menn, 1205 Geneva, Switzerland
Johannes Lammers
Consultant
1006 Lausanne, Switzerland
H. W. Anselm Wiskott
Research Scientist
Laboratory of Biomaterials, School of Dentistry,
University of Geneva
, 19 rue Barthélemy-Menn, 1205 Geneva, Switzerlande-mail: anselm@wiskott.com
J. Med. Devices. Mar 2009, 3(1): 011005 (7 pages)
Published Online: March 9, 2009
Article history
Received:
October 31, 2008
Revised:
December 18, 2008
Published:
March 9, 2009
Citation
Mekki, M., Durual, S., Scherrer, S. S., Lammers, J., and Wiskott, H. W. A. (March 9, 2009). "Optimization of Plasma Treatment, Manipulative Variables and Coating Composition for the Controlled Filling and Coating of a Microstructured Reservoir Stent." ASME. J. Med. Devices. March 2009; 3(1): 011005. https://doi.org/10.1115/1.3081394
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