Abstract
Targeted therapeutic delivery employs various technologies to enable precise delivery of therapeutic agents (drugs or cells) to specific areas within the human body. Compared with traditional drug administration routes, targeted therapeutic delivery has higher efficacy and reduced medication dosage and side effects. Soft microscale robotics have demonstrated great potential to precisely deliver drugs to the targeted region for performing designated therapeutic tasks. Microrobots can be actuated by various stimuli, such as heat, light, chemicals, acoustic waves, electric fields, and magnetic fields. Magnetic manipulation is well-suited for biomedical applications, as magnetic fields can safely permeate through organisms in a wide range of frequencies and amplitudes. Therefore, magnetic actuation is one of the most investigated and promising approaches for driving microrobots for targeted therapeutic delivery applications. To realize safe and minimally invasive therapies, biocompatibility and biodegradability are essential for these microrobots, which eliminate any post-treatment endoscopic or surgical removals. In this review, recent research efforts in the area of biodegradable magnetic microrobots used for targeted therapeutic delivery are summarized in terms of their materials, structure designs, and fabrication methods. In the end, remaining challenges and future prospects are discussed.
References
1.
Kim
,
J.
, and
De Jesus
,
O.
, 2023
, “
Medication Routes of Administration
,”
StatPearls Publishing
, Tampa, FL, accessed July 1, 2024, https://www.ncbi.nlm.nih.gov/books/NBK568677/2.
Trafton
,
A.
, 2009
, “Targeting
Tumors Using Tiny Gold Particles
,” MIT Tech Talk
,
53
, p. 4
.https://news.mit.edu/2009/gold-cancer-05043.
Mooney
,
D. J.
, and
Vandenburgh
,
H.
, 2008
, “
Cell Delivery Mechanisms for Tissue Repair
,” Cell Stem Cell
,
2
(3
), pp. 205
–213
.10.1016/j.stem.2008.02.0054.
Go
,
G.
,
Nguyen
,
V. D.
,
Jin
,
Z.
,
Park
,
J. O.
, and
Park
,
S.
, 2018
, “
A Thermo-Electromagnetically Actuated Microrobot for the Targeted Transport of Therapeutic Agents
,” Int. J. Control Autom. Syst.
,
16
(3
), pp. 1341
–1354
.10.1007/s12555-017-0060-z5.
Debata
,
S.
,
Kherani
,
N. A.
,
Panda
,
S. K.
, and
Singh
,
D. P.
, 2022
, “
Light-Driven Microrobots: Capture and Transport of Bacteria and Microparticles in a Fluid Medium
,” J. Mater. Chem. B
,
10
(40
), pp. 8235
–8243
.10.1039/D2TB01367C6.
Palima
,
D.
, and
Glückstad
,
J.
, 2013
, “
Gearing Up for Optical Microrobotics: Micromanipulation and Actuation of Synthetic Microstructures by Optical Forces
,” Laser Photon. Rev.
,
7
(4
), pp. 478
–494
.10.1002/lpor.2012000307.
Gao
,
W.
,
Dong
,
R.
,
Thamphiwatana
,
S.
,
Li
,
J.
,
Gao
,
W.
,
Zhang
,
L.
, and
Wang
,
J.
, 2015
, “
Artificial Micromotors in the Mouse's Stomach: A Step Toward In Vivo Use of Synthetic Motors
,” ACS Nano
,
9
(1
), pp. 117
–123
.10.1021/nn507097k8.
Solovev
,
A. A.
,
Mei
,
Y.
,
Ureña
,
E. B.
,
Huang
,
G.
, and
Schmidt
,
O. G.
, 2009
, “
Catalytic Microtubular Jet Engines Self‐Propelled by Accumulated Gas Bubbles
,” Small
,
5
(14
), pp. 1688
–1692
.10.1002/smll.2009000219.
Aghakhani
,
A.
,
Yasa
,
O.
,
Wrede
,
P.
, and
Sitti
,
M.
, 2020
, “
Acoustically Powered Surface-Slipping Mobile Microrobots
,” Proc. Natl. Acad. Sci.
,
117
(7
), pp. 3469
–3477
.10.1073/pnas.192009911710.
Guo
,
S.
,
Ge
,
Y.
,
Li
,
L.
, and
Liu
,
S.
, 2006
, “
Underwater Swimming Micro Robot Using IPMC Actuator
,” 2006 International Conference on Mechatronics and Automation
, Luoyang, China, June 25–28, pp. 249
–254
.10.1109/ICMA.2006.25750511.
Tyagi
,
M.
,
Spinks
,
G. M.
, and
Jager
,
E. W.
, 2021
, “
3D Printing Microactuators for Soft Microrobots
,” Soft Rob.
,
8
(1
), pp. 19
–27
.10.1089/soro.2019.012912.
Llacer‐Wintle
,
J.
,
Rivas‐Dapena
,
A.
,
Chen
,
X. Z.
,
Pellicer
,
E.
,
Nelson
,
B. J.
,
Puigmartí-Luis
,
J.
, and
Pané
,
S.
, 2021
, “
Biodegradable Small‐Scale Swimmers for Biomedical Applications
,” Adv. Mater.
,
33
(42
), p. 2102049
.10.1002/adma.20210204913.
Feng
,
Y.
,
Feng
,
L.
,
Dai
,
Y.
,
Bai
,
X.
,
Zhang
,
C.
,
Chen
,
Y.
, and
Arai
,
F.
, 2020
, “
A Novel and Controllable Cell-Based Microrobot in Real Vascular Network for Target Tumor Therapy
,” 2020 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS
), Las Vegas, NV, Oct. 25–29, pp. 2828
–2833
.10.1109/IROS45743.2020.934177414.
Lee
,
H.
,
Kim
,
D. I.
,
Kwon
,
S. H.
, and
Park
,
S.
, 2021
, “
Magnetically Actuated Drug Delivery Helical Microrobot With Magnetic Nanoparticle Retrieval Ability
,” ACS Appl. Mater. Interfaces
,
13
(17
), pp. 19633
–19647
.10.1021/acsami.1c0174215.
Nguyen
,
K. T.
,
Go
,
G.
,
Jin
,
Z.
,
Darmawan
,
B. A.
,
Yoo
,
A.
,
Kim
,
S.
,
Nan
,
M.
, et al., 2021
, “
A Magnetically Guided Self‐Rolled Microrobot for Targeted Drug Delivery, Real‐Time X‐Ray Imaging, and Microrobot Retrieval
,” Adv. Healthcare Mater.
,
10
(6
), p. 2001681
.10.1002/adhm.20200168116.
Peyer
,
K. E.
,
Tottori
,
S.
,
Qiu
,
F.
,
Zhang
,
L.
, and
Nelson
,
B. J.
, 2013
, “
Magnetic Helical Micromachines
,” Chem. Eur. J.
,
19
(1
), pp. 28
–38
.10.1002/chem.20120336417.
Jang
,
D.
,
Jeong
,
J.
,
Song
,
H.
, and
Chung
,
S. K.
, 2019
, “
Targeted Drug Delivery Technology Using Untethered Microrobots: A Review
,” J. Micromech. Microeng.
,
29
(5
), p. 053002
.10.1088/1361-6439/ab087d18.
Yan
,
X.
,
Zhou
,
Q.
,
Vincent
,
M.
,
Deng
,
Y.
,
Yu
,
J.
,
Xu
,
J.
,
Xu
,
T.
, et al., 2017
, “
Multifunctional Biohybrid Magnetite Microrobots for Imaging-Guided Therapy
,” Sci. Rob.
,
2
(12
), p. eaaq1155
.10.1126/scirobotics.aaq115519.
Li
,
J.
,
Li
,
X.
,
Luo
,
T.
,
Wang
,
R.
,
Liu
,
C.
,
Chen
,
S.
,
Li
,
D.
,
Yue
,
J.
,
Cheng
,
S. H.
, and
Sun
,
D.
, 2018
, “
Development of a Magnetic Microrobot for Carrying and Delivering Targeted Cells
,” Sci. Rob.
,
3
(19
), p. eaat8829
.10.1126/scirobotics.aat882920.
Kim
,
S.
,
Qiu
,
F.
,
Kim
,
S.
,
Ghanbari
,
A.
,
Moon
,
C.
,
Zhang
,
L.
,
Nelson
,
B. J.
, and
Choi
,
H.
, 2013
, “
Fabrication and Characterization of Magnetic Microrobots for Three‐Dimensional Cell Culture and Targeted Transportation
,” Adv. Mater.
,
25
(41
), pp. 5863
–5868
.10.1002/adma.20130148421.
Yasa
,
I. C.
,
Tabak
,
A. F.
,
Yasa
,
O.
,
Ceylan
,
H.
, and
Sitti
,
M.
, 2019
, “
3D‐Printed Microrobotic Transporters With Recapitulated Stem Cell Niche for Programmable and Active Cell Delivery
,” Adv. Funct. Mater.
,
29
(17
), p. 1808992
.10.1002/adfm.20180899222.
Noh
,
S.
,
Jeon
,
S.
,
Kim
,
E.
,
Oh
,
U.
,
Park
,
D.
,
Park
,
S. H.
,
Kim
,
S. W.
, et al., 2022
, “
A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells With Mass Production Capability
,” Small
,
18
(25
), p. 2107888
.10.1002/smll.20210788823.
Colombo
,
M.
,
Carregal-Romero
,
S.
,
Casula
,
M. F.
,
Gutiérrez
,
L.
,
Morales
,
M. P.
,
Böhm
,
I. B.
,
Heverhagen
,
J. T.
,
Prosperi
,
D.
, and
Parak
,
W. J.
, 2012
, “
Biological Applications of Magnetic Nanoparticles
,” Chem. Soc. Rev.
,
41
(11
), pp. 4306
–4334
.10.1039/c2cs15337h24.
Duguet
,
E.
,
Vasseur
,
S.
,
Mornet
,
S.
, and
Devoisselle
,
J. M.
, 2006
, “
Magnetic Nanoparticles and Their Applications in Medicine
,” Nanomedicine
,
1
(2
), pp. 157
–168
.10.2217/17435889.1.2.15725.
Lu
,
A. H.
,
Salabas
,
E. E.
, and
Schüth
,
F.
, 2007
, “
Magnetic Nanoparticles: Synthesis, Protection, Functionalization, and Application
,” Angew. Chem. Int. Ed. Engl.
,
46
(8
), pp. 1222
–1244
.10.1002/anie.20060286626.
Fuentes
,
O. P.
,
Trujillo
,
D. M.
,
Sánchez
,
M. E.
,
Abrego-Perez
,
A. L.
,
Osma
,
J. F.
, and
Cruz
,
J. C.
, 2024
, “
Embracing Sustainability in the Industry: A Study of Environmental, Economic, and Exergetic Performances in Large-Scale Production of Magnetite Nanoparticles
,” ACS Sustainable Chem. Eng.
,
12
(2
), pp. 760
–772
.10.1021/acssuschemeng.3c0500027.
Guillén-Pacheco
,
A.
,
Ardila
,
Y.
,
Peñaranda
,
P. A.
,
Bejarano
,
M.
,
Rivas
,
R.
,
Osma
,
J. F.
, and
Akle
,
V.
, 2024
, “
Low Toxicity of Magnetite-Based Modified Bionanocomposites With Potential Application for Wastewater Treatment: Evaluation in a Zebrafish Animal Model
,” Chemosphere
,
358
, p. 142081
.10.1016/j.chemosphere.2024.14208128.
Vert
,
M.
,
Doi
,
Y.
,
Hellwich
,
K.-H.
,
Hess
,
M.
,
Hodge
,
P.
,
Kubisa
,
P.
,
Rinaudo
,
M.
, and
Schué
,
F.
, 2012
, “
Terminology for Biorelated Polymers and Applications (IUPAC Recommendations 2012)
,” Pure Appl. Chem.
,
84
(2
), pp. 377
–410
.10.1351/PAC-REC-10-12-0429.
Huang
,
H.
,
Dong
,
C.
,
Feng
,
W.
,
Wang
,
Y.
,
Huang
,
B.
, and
Chen
,
Y.
, 2022
, “
Biomedical Engineering of Two-Dimensional MXenes
,” Adv. Drug Delivery Rev.
,
184
, p. 114178
.10.1016/j.addr.2022.11417830.
Li
,
C.
,
Guo
,
C.
,
Fitzpatrick
,
V.
,
Ibrahim
,
A.
,
Zwierstra
,
M. J.
,
Hanna
,
P.
,
Lechtig
,
A.
,
Nazarian
,
A.
,
Lin
,
S. J.
, and
Kaplan
,
D. L.
, 2019
, “
Design of Biodegradable, Implantable Devices Towards Clinical Translation
,” Nat. Rev. Mater.
,
5
(1
), pp. 61
–81
.10.1038/s41578-019-0150-z31.
Ye
,
M.
,
Zhou
,
Y.
,
Zhao
,
H.
,
Wang
,
Z.
,
Nelson
,
B. J.
, and
Wang
,
X.
, 2023
, “
A Review of Soft Microrobots: Material, Fabrication, and Actuation
,” Adv. Intell. Syst.
,
5
(11
), p. 2300311
.10.1002/aisy.20230031132.
Li
,
J.
, and
Yu
,
J.
, 2023
, “
Biodegradable Microrobots and Their Biomedical Applications: A Review
,” Nanomaterials
,
13
(10
), p. 1590
.10.3390/nano1310159033.
Hutmacher
,
D. W.
,
Goh
,
J. C. H.
, and
Teoh
,
S. H.
, 2001
, “
An Introduction to Biodegradable Materials for Tissue Engineering Applications
,” Ann. Acad. Med. Singapore
,
30
(2
), pp. 183
–191
.https://www.annals.edu.sg/pdf_0301/gohj.pdf34.
Park
,
J.
,
Jin
,
C.
,
Lee
,
S.
,
Kim
,
J. Y.
, and
Choi
,
H.
, 2019
, “
Magnetically Actuated Degradable Microrobots for Actively Controlled Drug Release and Hyperthermia Therapy
,” Adv. Healthcare Mater.
,
8
(16
), p. 1900213
.10.1002/adhm.20190021335.
Sun
,
H. C. M.
,
Liao
,
P.
,
Wei
,
T.
,
Zhang
,
L.
, and
Sun
,
D.
, 2020
, “
Magnetically Powered Biodegradable Microswimmers
,” Micromachines
,
11
(4
), p. 404
.10.3390/mi1104040436.
Peters
,
C.
,
Hoop
,
M.
,
Pané
,
S.
,
Nelson
,
B. J.
, and
Hierold
,
C.
, 2016
, “
Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests
,” Adv. Mater.
,
28
(3
), pp. 533
–538
.10.1002/adma.20150311237.
Heller
,
C.
,
Schwentenwein
,
M.
,
Russmueller
,
G.
,
Varga
,
F.
,
Stampfl
,
J.
, and
Liska
,
R.
, 2009
, “
Vinyl Esters: Low Cytotoxicity Monomers for the Fabrication of Biocompatible 3D Scaffolds by Lithography Based Additive Manufacturing
,” J. Polym. Sci. A: Polym. Chem.
,
47
(24
), pp. 6941
–6954
.10.1002/pola.2373438.
Dong
,
M.
,
Wang
,
X.
,
Chen
,
X. Z.
,
Mushtaq
,
F.
,
Deng
,
S.
,
Zhu
,
C.
,
Torlakcik
,
H.
, et al., 2020
, “
3D‐Printed Soft Magnetoelectric Microswimmers for Delivery and Differentiation of Neuron‐Like Cells
,” Adv. Funct. Mater.
,
30
(17
), p. 1910323
.10.1002/adfm.20191032339.
Hou
,
Y.
,
Wang
,
H.
,
Zhong
,
S.
,
Qiu
,
Y.
,
Shi
,
Q.
,
Sun
,
T.
,
Huang
,
Q.
, and
Fukuda
,
T.
, 2023
, “
Design and Control of a Surface-Dimple-Optimized Helical Microdrill for Motions in High-Viscosity Fluids
,” IEEE ASME Trans. Mechatron.
,
28
(1
), pp. 429
–439
.10.1109/TMECH.2022.320101240.
Terzopoulou
,
A.
,
Wang
,
X.
,
Chen
,
X. Z.
,
Palacios-Corella
,
M.
,
Pujante
,
C.
,
Herrero-Martín
,
J.
,
Qin
,
X. H.
, et al., 2020
, “
Biodegradable Metal–Organic Framework‐Based Microrobots (MOFBOTs)
,” Adv. Healthcare Mater.
,
9
(20
), p. 2001031
.10.1002/adhm.20200103141.
Wang
,
X.
,
Qin
,
X. H.
,
Hu
,
C.
,
Terzopoulou
,
A.
,
Chen
,
X. Z.
,
Huang
,
T. Y.
,
Maniura-Weber
,
K.
,
Salvador Pané
,
S.
, and
Nelson
,
B.
, 2018
, “
3D Printed Enzymatically Biodegradable Soft Helical Microswimmers
,” Adv. Funct. Mater.
,
28
(45
), p. 1804107
.10.1002/adfm.20180410742.
Vaes
,
G.
, 1980
, “
Cell-to-Cell Interactions in the Secretion of Enzymes of Connective-Tissue Breakdown, Collagenase and Proteoglycan-Degrading Neutral Proteases—A Review
,” Agents Actions
,
10
(6
), pp. 474
–485
.10.1007/BF0202414543.
Kim
,
D.
,
Lee
,
H.
,
Kwon
,
S.
,
Choi
,
H.
, and
Park
,
S.
, 2019
, “
Magnetic Nano-Particles Retrievable Biodegradable Hydrogel Microrobot
,” Sens. Actuators B: Chem.
,
289
, pp. 65
–77
.10.1016/j.snb.2019.03.03044.
Kim
,
J.
,
Jeon
,
S.
,
Lee
,
J.
,
Lee
,
S.
,
Lee
,
J.
,
Jeon
,
B. O.
,
Jang
,
J.
, and
Choi
,
H.
, 2018
, “
A Simple and Rapid Fabrication Method for Biodegradable Drug-Encapsulating Microrobots Using Laser Micromachining, and Characterization Thereof
,” Sens. Actuators B: Chem.
,
266
, pp. 276
–287
.10.1016/j.snb.2018.03.03345.
Zahn
,
D.
,
Weidner
,
A.
,
Saatchi
,
K.
,
Häfeli
,
U. O.
, and
Dutz
,
S.
, 2019
, “
Biodegradable Magnetic Microspheres for Drug Targeting, Temperature Controlled Drug Release, and Hyperthermia
,” Curr. Dir. Biomed. Eng.
,
5
(1
), pp. 161
–164
.10.1515/cdbme-2019-004146.
Yang
,
R.
,
Zhu
,
S.
,
Zhang
,
L.
,
Niu
,
F.
, and
Liu
,
S.
, 2021
, “
Magnetic Microswimmers With Infrared‐Induced Shape Transformation
,” Micro Nano Lett.
,
16
(12
), pp. 582
–590
.10.1049/mna2.1208647.
Pacheco
,
M.
,
Mayorga-Martinez
,
C.
,
Viktorova
,
J.
,
Ruml
,
T.
,
Escarpa
,
A.
, and
Pumera
,
M.
, 2022
, “
Microrobotic Carrier With Enzymatically Encoded Drug Release in the Presence of Pancreatic Cancer Cells Via Programmed Self-Destruction
,” Appl. Mater. Today
,
27
, p. 101494
.10.1016/j.apmt.2022.10149448.
Zhao
,
P.
,
Qu
,
F.
,
Fu
,
H.
,
Zhao
,
J.
,
Guo
,
J.
,
Xu
,
J.
,
Ho
,
Y. P.
,
Chan
,
M. L.
, and
Bian
,
L.
, 2023
, “
Water-Immiscible Coacervate as a Liquid Magnetic Robot for Intravascular Navigation
,” J. Am. Chem. Soc.
,
145
(6
), pp. 3312
–3317
.10.1021/jacs.2c1328749.
Lee
,
H.
,
Choi
,
H.
,
Lee
,
M.
, and
Park
,
S.
, 2018
, “
Preliminary Study on Alginate/NIPAM Hydrogel-Based Soft Microrobot for Controlled Drug Delivery Using Electromagnetic Actuation and Near-Infrared Stimulus
,” Biomed. Microdevices
,
20
(4
), p. 103
.10.1007/s10544-018-0344-y50.
Mair
,
L. O.
,
Chowdhury
,
S.
,
Paredes-Juarez
,
G. A.
,
Guix
,
M.
,
Bi
,
C.
,
Johnson
,
B.
,
English
,
B. W.
, et al., 2019
, “
Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery
,” Micromachines
,
10
(4
), p. 230
.10.3390/mi1004023051.
Lin
,
S.
,
Sangaj
,
N.
,
Razafiarison
,
T.
,
Zhang
,
C.
, and
Varghese
,
S.
, 2011
, “
Influence of Physical Properties of Biomaterials on Cellular Behavior
,” Pharm. Res.
,
28
(6
), pp. 1422
–1430
.10.1007/s11095-011-0378-952.
Buchroithner
,
B.
,
Hartmann
,
D.
,
Mayr
,
S.
,
Oh
,
Y. J.
,
Sivun
,
D.
,
Karner
,
A.
,
Buchegger
,
B.
, et al., 2020
, “
3D Multiphoton Lithography Using Biocompatible Polymers With Specific Mechanical Properties
,” Nanoscale Adv.
,
2
(6
), pp. 2422
–2428
.10.1039/D0NA00154F53.
Belqat
,
M.
,
Wu
,
X.
,
Gomez
,
L. P. C.
,
Malval
,
J. P.
,
Dominici
,
S.
,
Leuschel
,
B.
,
Spangenberg
,
A.
, and
Mougin
,
K.
, 2021
, “
Tuning Nanomechanical Properties of Microstructures Made by 3D Direct Laser Writing
,” Addit. Manuf.
,
47
, p. 102232
.10.1016/j.addma.2021.10223254.
Wu
,
Y.
,
Xiang
,
Y.
,
Fang
,
J.
,
Li
,
X.
,
Lin
,
Z.
,
Dai
,
G.
,
Yin
,
J.
,
Wei
,
P.
, and
Zhang
,
D.
, 2019
, “
The Influence of the Stiffness of GelMA Substrate on the Outgrowth of PC12 Cells
,” Biosci. Rep.
,
39
(1
), p. BSR20181748
.10.1042/BSR2018174855.
Marques
,
D. R.
,
Santos
,
L. A. D.
,
Schopf
,
L. F.
, and
Fraga
,
J. C. S. D.
, 2013
, “
Analysis of Poly (Lactic-Co-Glycolic Acid)/Poly (Isoprene) Polymeric Blend for Application as Biomaterial
,” Polímeros
,
23
(5
), pp. 579
–584
.10.4322/polimeros.2013.09956.
Jain
,
N.
,
Singh
,
V. K.
, and
Chauhan
,
S.
, 2017
, “
A Review on Mechanical and Water Absorption Properties of Polyvinyl Alcohol Based Composites/Films
,” J. Mech. Behav. Biomed. Mater.
,
26
(5–6
), pp. 213
–222
.10.1515/jmbm-2017-002757.
Eshraghi
,
S.
, and
Das
,
S.
, 2010
, “
Mechanical and Microstructural Properties of Polycaprolactone Scaffolds With 1-D, 2-D, and 3-D Orthogonally Oriented Porous Architectures Produced by Selective Laser Sintering
,” Acta Biomater.
,
6
(7
), pp. 2467
–2476
.10.1016/j.actbio.2010.02.00258.
MakeItFrom.com, 2020, “
Polyetherimide
,” MakeItFrom.com, Lake Mary, FL, accessed Mar. 1, 2024, https://www.makeitfrom.com/material-properties/Polyetherimide-PEI59.
Iza
,
M.
,
Stoianovici
,
G.
,
Viora
,
L.
,
Grossiord
,
J. L.
, and
Couarraze
,
G.
, 1998
, “
Hydrogels of Poly (Ethylene Glycol): Mechanical Characterization and Release of a Model Drug
,” J. Controlled Release
,
52
(1–2
), pp. 41
–51
.10.1016/S0168-3659(97)00191-060.
Ikehata
,
A.
, and
Ushiki
,
H.
, 2002
, “
Effect of Salt on the Elastic Modulus of Poly (N-Isopropylacrylamide) Gels
,” Polymer
,
43
(7
), pp. 2089
–2094
.10.1016/S0032-3861(01)00791-161.
Santos Rosalem
,
G.
,
Gonzales Torres
,
L. A.
,
de Las Casas
,
E. B.
,
Mathias
,
F. A. S.
,
Ruiz
,
J. C.
, and
Carvalho
,
M. G. R.
, 2020
, “
Microfluidics and Organ-on-a-Chip Technologies: A Systematic Review of the Methods Used to Mimic Bone Marrow
,” PLoS One
,
15
(12
), p. e0243840
.10.1371/journal.pone.024384062.
Zhang
,
B.
,
Galluzzi
,
M.
,
Zhou
,
G.
, and
Yu
,
H.
, 2023
, “
A Study of Macrophage Mechanical Properties and Functional Modulation Based on the Young's Modulus of PLGA-PEG Fibers
,” Biomater. Sci.
,
11
(1
), pp. 153
–161
.10.1039/D2BM01351G63.
Yan
,
X.
,
Xu
,
J.
,
Zhou
,
Q.
,
Jin
,
D.
,
Vong
,
C. I.
,
Feng
,
Q.
,
Ng
,
D. H.
,
Bian
,
L.
, and
Zhang
,
L.
, 2019
, “
Molecular Cargo Delivery Using Multicellular Magnetic Microswimmers
,” Appl. Mater. Today
,
15
, pp. 242
–251
.10.1016/j.apmt.2019.02.00664.
Xie
,
L.
,
Pang
,
X.
,
Yan
,
X.
,
Dai
,
Q.
,
Lin
,
H.
,
Ye
,
J.
,
Cheng
,
Y.
, et al., 2020
, “
Photoacoustic Imaging-Trackable Magnetic Microswimmers for Pathogenic Bacterial Infection Treatment
,” ACS Nano
,
14
(3
), pp. 2880
–2893
.10.1021/acsnano.9b0673165.
Yan
,
X.
,
Zhou
,
Q.
,
Yu
,
J.
,
Xu
,
T.
,
Deng
,
Y.
,
Tang
,
T.
,
Feng
,
Q.
, et al., 2015
, “
Magnetite Nanostructured Porous Hollow Helical Microswimmers for Targeted Delivery
,” Adv. Funct. Mater.
,
25
(33
), pp. 5333
–5342
.10.1002/adfm.20150224866.
Carlsen
,
R. W.
,
Edwards
,
M. R.
,
Zhuang
,
J.
,
Pacoret
,
C.
, and
Sitti
,
M.
, 2014
, “
Magnetic Steering Control of Multi-Cellular Bio-Hybrid Microswimmers
,” Lab Chip
,
14
(19
), pp. 3850
–3859
.10.1039/C4LC00707G67.
Zhang
,
Y.
,
Zhang
,
L.
,
Yang
,
L.
,
Vong
,
C. I.
,
Chan
,
K. F.
,
Wu
,
W. K. K.
,
Kwong
,
T. N. Y.
, et al., 2019
, “
Real-Time Tracking of Fluorescent Magnetic Spore-Based Microrobots for Remote Detection of C. diff Toxins
,” Sci. Adv.
,
5
(1
), p. eaau9650
.10.1126/sciadv.aau965068.
Kim
,
J.
,
Park
,
H.
, and
Yoon
,
C.
, 2022
, “
Advances in Biodegradable Soft Robots
,” Polymers
,
14
(21
), p. 4574
.10.3390/polym1421457469.
Mushtaq
,
F.
,
Chen
,
X.
,
Staufert
,
S.
,
Torlakcik
,
H.
,
Wang
,
X.
,
Hoop
,
M.
,
Gerber
,
A.
, et al., 2019
, “
On-the-Fly Catalytic Degradation of Organic Pollutants Using Magneto-Photoresponsive Bacteria-Templated Microcleaners
,” J. Mater. Chem. A
,
7
(43
), pp. 24847
–24856
.10.1039/C9TA06290D70.
Steager
,
E. B.
,
Selman Sakar
,
M.
,
Magee
,
C.
,
Kennedy
,
M.
,
Cowley
,
A.
, and
Kumar
,
V.
, 2013
, “
Automated Biomanipulation of Single Cells Using Magnetic Microrobots
,” Int. J. Rob. Res.
,
32
(3
), pp. 346
–359
.10.1177/027836491247238171.
Zhang
,
L.
,
Abbott
,
J. J.
,
Dong
,
L.
,
Peyer
,
K. E.
,
Kratochvil
,
B. E.
,
Zhang
,
H.
,
Bergeles
,
C.
, and
Nelson
,
B. J.
, 2009
, “
Characterizing the Swimming Properties of Artificial Bacterial Flagella
,” Nano Lett.
,
9
(10
), pp. 3663
–3667
.10.1021/nl901869j72.
Gao
,
W.
,
Sattayasamitsathit
,
S.
,
Manesh
,
K. M.
,
Weihs
,
D.
, and
Wang
,
J.
, 2010
, “
Magnetically Powered Flexible Metal Nanowire Motors
,” J. Am. Chem. Soc.
,
132
(41
), pp. 14403
–14405
.10.1021/ja107234973.
Li
,
T.
,
Li
,
J.
,
Zhang
,
H.
,
Chang
,
X.
,
Song
,
W.
,
Hu
,
Y.
,
Shao
,
G.
, et al., 2016
, “
Magnetically Propelled Fish‐Like Nanoswimmers
,” Small
,
12
(44
), pp. 6098
–6105
.10.1002/smll.20160184674.
Kim
,
S.
,
Lee
,
S.
,
Lee
,
J.
,
Nelson
,
B. J.
,
Zhang
,
L.
, and
Choi
,
H.
, 2016
, “
Fabrication and Manipulation of Ciliary Microrobots With Non-Reciprocal Magnetic Actuation
,” Sci. Rep.
,
6
(1
), p. 30713
.10.1038/srep3071375.
Qiu
,
T.
,
Lee
,
T.-C.
,
Mark
,
A. G.
,
Morozov
,
K. I.
,
Münster
,
R.
,
Mierka
,
O.
,
Turek
,
S.
,
Leshansky
,
A. M.
, and
Fischer
,
P.
, 2014
, “
Swimming by Reciprocal Motion at Low Reynolds Number
,” Nat. Commun.
,
5
(1
), p. 5119
.10.1038/ncomms611976.
Kline
,
T. R.
,
Paxton
,
W. F.
,
Mallouk
,
T. E.
, and
Sen
,
A.
, 2005
, “
Catalytic Nanomotors: Remote‐Controlled Autonomous Movement of Striped Metallic Nanorods
,” Angew. Chem. Int. Ed. Engl.
,
44
(5
), pp. 744
–746
.10.1002/anie.20046189077.
Peyer
,
K. E.
,
Zhang
,
L.
, and
Nelson
,
B. J.
, 2013
, “
Bio-Inspired Magnetic Swimming Microrobots for Biomedical Applications
,” Nanoscale
,
5
(4
), pp. 1259
–1272
.10.1039/C2NR32554C78.
Berg
,
H. C.
, and
Anderson
,
R. A.
, 1973
, “
Bacteria Swim by Rotating Their Flagellar Filaments
,” Nature
,
245
(5425
), pp. 380
–382
.10.1038/245380a079.
Purcell
,
E. M.
, 1977
, “
Life at Low Reynolds Number
,” Am. J. Phys.
,
45
(1
), pp. 3
–11
.10.1119/1.1090380.
Bell
,
D. J.
,
Leutenegger
,
S.
,
Hammar
,
K. M.
,
Dong
,
L. X.
, and
Nelson
,
B. J.
, 2007
, “
Flagella-Like Propulsion for Microrobots Using a Nanocoil and a Rotating Electromagnetic Field
,” Proceedings of the 2007 IEEE International Conference on Robotics and Automation
, Rome, Italy, Apr. 10–14, pp. 1128
–1133
.10.1109/ROBOT.2007.36313681.
Zhang
,
L.
,
Peyer
,
K. E.
,
Petit
,
T.
,
Kratochvil
,
B. E.
, and
Nelson
,
B. J.
, 2010
, “
Motion Control of Artificial Bacterial Flagella
,” Tenth IEEE International Conference on Nanotechnology
, Ilsan, South Korea, Aug. 17–20, pp. 893
–896
.10.1109/NANO.2010.569783982.
Zhang
,
L.
,
Abbott
,
J. J.
,
Dong
,
L.
,
Kratochvil
,
B. E.
,
Bell
,
D.
, and
Nelson
,
B. J.
, 2009
, “
Artificial Bacterial Flagella: Fabrication and Magnetic Control
,” Appl. Phys. Lett.
,
94
(6
), p. 064107
.10.1063/1.307965583.
Zhang
,
L.
,
Peyer
,
K. E.
, and
Nelson
,
B. J.
, 2010
, “
Artificial Bacterial Flagella for Micromanipulation
,” Lab Chip
,
10
(17
), pp. 2203
–2215
.10.1039/c004450b84.
Ghosh
,
A.
, and
Fischer
,
P.
, 2009
, “
Controlled Propulsion of Artificial Magnetic Nanostructured Propellers
,” Nano Lett.
,
9
(6
), pp. 2243
–2245
.10.1021/nl900186w85.
Hwang
,
G.
,
Haliyo
,
S.
, and
Régnier
,
S.
, 2010
, “
Remotely Powered Propulsion of Helical Nanobelts
,” Robotics: Science and Systems
, Zaragoza, Spain, June 27–30, pp. 1–8.https://www.roboticsproceedings.org/rss06/p39.pdf86.
Hwang
,
G.
,
Braive
,
R.
,
Couraud
,
L.
,
Cavanna
,
A.
,
Abdelkarim
,
O.
,
Robert-Philip
,
I.
,
Beveratos
,
A.
,
Sagnes
,
I.
,
Haliyo
,
S.
, and
Régnier
,
S.
, 2011
, “
Electro-Osmotic Propulsion of Helical Nanobelt Swimmers
,” Int. J. Rob. Res.
,
30
(7
), pp. 806
–819
.10.1177/027836491140723187.
Khalil
,
I. S.
,
Tabak
,
A. F.
,
Hamed
,
Y.
,
Tawakol
,
M.
,
Klingner
,
A.
,
El Gohary
,
N.
,
Mizaikoff
,
B.
, and
Sitti
,
M.
, 2018
, “
Independent Actuation of Two-Tailed Microrobots
,” IEEE Rob. Autom. Lett.
,
3
(3
), pp. 1703
–1710
.10.1109/LRA.2018.280179388.
Hamed
,
Y.
,
Tawakol
,
M.
,
El Zahar
,
L.
,
Klingner
,
A.
,
Abdennadher
,
S.
, and
Khalil
,
I. S.
, 2018
, “
Realization of a Soft Microrobot With Multiple Flexible Flagella
,” 2018 Seventh IEEE International Conference on Biomedical Robotics and Biomechatronics (Biorob
), Enschede, The Netherlands, Aug. 26–29, pp. 61
–66
.10.1109/BIOROB.2018.848800889.
Xu
,
T.
,
Gilgueng
,
H.
,
Nicolas
,
A.
, and
Stéphane
,
R.
, 2014
, “
Modeling and Swimming Property Characterizations of Scaled-Up Helical Microswimmers
,” IEEE ASME Trans. Mechatron.
,
19
(3
), pp. 1069
–1079
.10.1109/TMECH.2013.226980290.
Ceylan
,
H.
,
Yasa
,
I. C.
,
Yasa
,
O.
,
Tabak
,
A.
,
Giltinan
,
J.
, and
Sitti
,
M.
, 2019
, “
3D-Printed Biodegradable Microswimmer for Theranostic Cargo Delivery and Release
,” ACS Nano
,
13
(3
), pp. 3353
–3362
.10.1021/acsnano.8b0923391.
Pak
,
O. S.
,
Gao
,
W.
,
Wang
,
J.
, and
Lauga
,
E.
, 2011
, “
High-Speed Propulsion of Flexible Nanowire Motors: Theory and Experiments
,” Soft Matter
,
7
(18
), pp. 8169
–8181
.10.1039/c1sm05503h92.
Dreyfus
,
R.
,
Baudry
,
J.
,
Roper
,
M. L.
,
Fermigier
,
M.
,
Stone
,
H. A.
, and
Bibette
,
J.
, 2005
, “
Microscopic Artificial Swimmers
,” Nature
,
437
(7060
), pp. 862
–865
.10.1038/nature0409093.
Ludwig
,
W.
, 1930
, “
Zur Theorie der Flimmerbewegung (Dynamik, Nutzeffekt, Energiebilanz)
,” J. Comp. Physiol. A: Neuroethol. Sens. Neural Behav. Physiol.
,
13
(3
), pp. 397
–504
.10.1007/BF0033817194.
Shah
,
A. S.
,
Ben-Shahar
,
Y.
,
Moninger
,
T. O.
,
Kline
,
J. N.
, and
Welsh
,
M. J.
, 2009
, “
Motile Cilia of Human Airway Epithelia Are Chemosensory
,” Science
,
325
(5944
), pp. 1131
–1134
.10.1126/science.117386995.
Ghanbari
,
A.
, and
Bahrami
,
M.
, 2011
, “
A Novel Swimming Microrobot Based on Artificial Cilia for Biomedical Applications
,” J. Intell. Rob. Syst.
,
63
(3–4
), pp. 399
–416
.10.1007/s10846-010-9516-696.
Dodampegama
,
S.
,
Mudugamuwa
,
A.
,
Konara
,
M.
,
Perera
,
N.
,
De Silva
,
D.
,
Roshan
,
U.
,
Amarasinghe
,
R.
,
Jayaweera
,
N.
, and
Tamura
,
H.
, 2022
, “
A Review on the Motion of Magnetically Actuated Bio-Inspired Microrobots
,” Appl. Sci.
,
12
(22
), p. 11542
.10.3390/app12221154297.
Xing
,
L.
,
Liao
,
P.
,
Mo
,
H.
,
Li
,
D.
, and
Sun
,
D.
, 2021
, “
Preformation Characterization of a Torque-Driven Magnetic Microswimmer With Multi-Segment Structure
,” IEEE Access
,
9
, pp. 29279
–29292
.10.1109/ACCESS.2021.305852798.
Palagi
,
S.
, and
Fischer
,
P.
, 2018
, “
Bioinspired Microrobots
,” Nat. Rev. Mater.
,
3
(6
), pp. 113
–124
.10.1038/s41578-018-0016-999.
Ng
,
C. S. X.
,
Tan
,
M. W. M.
,
Xu
,
C.
,
Yang
,
Z.
,
Lee
,
P. S.
, and
Lum
,
G. Z.
, 2021
, “
Locomotion of Miniature Soft Robots
,” Adv. Mater.
,
33
(19
), p. 2003558
.10.1002/adma.202003558100.
Hussein
,
H.
,
Damdam
,
A.
,
Ren
,
L.
,
Obeid Charrouf
,
Y.
,
Challita
,
J.
,
Zwain
,
M.
, and
Fariborzi
,
H.
, 2023
, “
Actuation of Mobile Microbots: A Review
,” Adv. Intell. Syst.
,
5
(9
), p. 2300168
.10.1002/aisy.202300168101.
Wang
,
X.
,
Hu
,
C.
,
Pané
,
S.
, and
Nelson
,
B. J.
, 2022
, “
Dynamic Modeling of Magnetic Helical Microrobots
,” IEEE Rob. Autom. Lett.
,
7
(2
), pp. 1682
–1688
.10.1109/LRA.2020.3049112102.
Huang
,
H. W.
,
Uslu
,
F. E.
,
Katsamba
,
P.
,
Lauga
,
E.
,
Sakar
,
M. S.
, and
Nelson
,
B. J.
, 2019
, “
Adaptive Locomotion of Artificial Microswimmers
,” Sci. Adv.
,
5
(1
), p. eaau1532
.10.1126/sciadv.aau1532103.
Huang
,
T. Y.
,
Sakar
,
M. S.
,
Mao
,
A.
,
Petruska
,
A. J.
,
Qiu
,
F.
,
Chen
,
X. B.
,
Kennedy
,
S.
,
Mooney
,
D.
, and
Nelson
,
B. J.
, 2015
, “
3D Printed Microtransporters: Compound Micromachines for Spatiotemporally Controlled Delivery of Therapeutic Agents
,” Adv. Mater.
,
27
(42
), pp. 6644
–6650
.10.1002/adma.201503095104.
Huang
,
T. Y.
,
Qiu
,
F.
,
Tung
,
H. W.
,
Peyer
,
K. E.
,
Shamsudhin
,
N.
,
Pokki
,
J.
,
Zhang
,
L.
,
Chen
,
X. B.
,
Nelson
,
B. J.
, and
Sakar
,
M. S.
, 2014
, “
Cooperative Manipulation and Transport of Microobjects Using Multiple Helical Microcarriers
,” RSC Adv.
,
4
(51
), pp. 26771
–26776
.10.1039/C4RA02260B105.
Dong
,
X.
, and
Sitti
,
M.
, 2020
, “
Controlling Two-Dimensional Collective Formation and Cooperative Behavior of Magnetic Microrobot Swarms
,” Int. J. Rob. Res.
,
39
(5
), pp. 617
–638
.10.1177/0278364920903107106.
Xie
,
H.
,
Sun
,
M.
,
Fan
,
X.
,
Lin
,
Z.
,
Chen
,
W.
,
Wang
,
L.
,
Dong
,
L.
, and
He
,
Q.
, 2019
, “
Reconfigurable Magnetic Microrobot Swarm: Multimode Transformation, Locomotion, and Manipulation
,” Sci. Rob.
,
4
(28
), p. eaav8006
.10.1126/scirobotics.aav8006107.
Behrens
,
M. R.
, and
Ruder
,
W. C.
, 2022
, “
Smart Magnetic Microrobots Learn to Swim With Deep Reinforcement Learning
,” Adv. Intell. Syst.
,
4
(10
), p. 2200023
.10.1002/aisy.202200023108.
Hou
,
Y.
,
Wang
,
H.
,
Fu
,
R.
,
Wang
,
X.
,
Yu
,
J.
,
Zhang
,
S.
,
Huang
,
Q.
,
Sun
,
Y.
, and
Fukuda
,
T.
, 2023
, “
A Review on Microrobots Driven by Optical and Magnetic Fields
,” Lab Chip
,
23
(5
), pp. 848
–868
.10.1039/D2LC00573E109.
Pironneau
,
O.
, 1973
, “
On Optimum Profiles in Stokes Flow
,” J. Fluid Mech.
,
59
(1
), pp. 117
–128
.10.1017/S002211207300145X110.
Bourot
,
J. M.
, 1974
, “
On the Numerical Computation of the Optimum Profile in Stokes Flow
,” J. Fluid Mech.
,
65
(3
), pp. 513
–515
.10.1017/S0022112074001510111.
Diller
,
E.
, and
Sitti
,
M.
, 2014
, “
Three‐Dimensional Programmable Assembly by Untethered Magnetic Robotic Micro‐Grippers
,” Adv. Funct. Mater.
,
24
(28
), pp. 4397
–4404
.10.1002/adfm.201400275112.
Wang
,
Q.
,
Chan
,
K. F.
,
Schweizer
,
K.
,
Du
,
X.
,
Jin
,
D.
,
Yu
,
S. C. H.
,
Nelson
,
B. J.
, and
Zhang
,
L.
, 2021
, “
Ultrasound Doppler-Guided Real-Time Navigation of a Magnetic Microswarm for Active Endovascular Delivery
,” Sci. Adv.
,
7
(9
), p. eabe5914
.10.1126/sciadv.abe5914113.
Kummer
,
M. P.
,
Abbott
,
J. J.
,
Kratochvil
,
B. E.
,
Borer
,
R.
,
Sengul
,
A.
, and
Nelson
,
B. J.
, 2010
, “
OctoMag: An Electromagnetic System for 5-DOF Wireless Micromanipulation
,” IEEE Trans. Rob.
,
26
(6
), pp. 1006
–1017
.10.1109/TRO.2010.2073030114.
Erni
,
S.
,
Schürle
,
S.
,
Fakhraee
,
A.
,
Kratochvil
,
B. E.
, and
Nelson
,
B. J.
, 2013
, “
Comparison, Optimization, and Limitations of Magnetic Manipulation Systems
,” J. Micro-Bio Rob.
,
8
(3–4
), pp. 107
–120
.10.1007/s12213-013-0070-8115.
Petruska
,
A. J.
, 2020
, “
Open-Loop Orientation Control Using Dynamic Magnetic Fields
,” IEEE Rob. Autom. Lett.
,
5
(4
), pp. 5472
–5476
.10.1109/LRA.2020.3009070116.
Sitt
,
A.
,
Soukupova
,
J.
,
Miller
,
D.
,
Verdi
,
D.
,
Zboril
,
R.
,
Hess
,
H.
, and
Lahann
,
J.
, 2016
, “
Microscale Rockets and Picoliter Containers Engineered From Electrospun Polymeric Microtubes
,” Small
,
12
(11
), pp. 1432
–1439
.10.1002/smll.201503467117.
Wang
,
D.
,
Zhao
,
G.
,
Chen
,
C.
,
Zhang
,
H.
,
Duan
,
R.
,
Zhang
,
D.
,
Li
,
M.
, and
Dong
,
B.
, 2019
, “
One-Step Fabrication of Dual Optically/Magnetically Modulated Walnut-Like Micromotor
,” Langmuir
,
35
(7
), pp. 2801
–2807
.10.1021/acs.langmuir.8b02904118.
Su
,
Y.
,
Qiu
,
T.
,
Song
,
W.
,
Han
,
X.
,
Sun
,
M.
,
Wang
,
Z.
,
Xie
,
H.
,
Dong
,
M.
, and
Chen
,
M.
, 2021
, “
Melt Electrospinning Writing of Magnetic Microrobots
,” Adv. Sci.
,
8
(3
), p. 2003177
.10.1002/advs.202003177119.
Tan
,
L.
, and
Cappelleri
,
D. J.
, 2023
, “
Design, Fabrication, and Characterization of a Helical Adaptive Multi-Material Microrobot (HAMMR)
,” IEEE Rob. Autom. Lett.
,
8
(3
), pp. 1723
–1730
.10.1109/LRA.2023.3242164120.
Wei
,
T.
,
Liu
,
J.
,
Li
,
D.
,
Chen
,
S.
,
Zhang
,
Y.
,
Li
,
J.
,
Fan
,
L.
, et al., 2020
, “
Development of Magnet‐Driven and Image‐Guided Degradable Microrobots for the Precise Delivery of Engineered Stem Cells for Cancer Therapy
,” Small
,
16
(41
), p. 1906908
.10.1002/smll.201906908121.
Limberg
,
D. K.
,
Kang
,
J. H.
, and
Hayward
,
R. C.
, 2022
, “
Triplet–Triplet Annihilation Photopolymerization for High-Resolution 3D Printing
,” J. Am. Chem. Soc.
,
144
(12
), pp. 5226
–5232
.10.1021/jacs.1c11022122.
Bozuyuk
,
U.
,
Yasa
,
O.
,
Yasa
,
C.
,
Ceylan
,
H.
,
Kizilel
,
S.
, and
Sitti
,
M.
, 2018
, “
Light-Triggered Drug Release From 3D-Printed Magnetic Chitosan Microswimmers
,” ACS Nano
,
12
(9
), pp. 9617
–9625
.10.1021/acsnano.8b05997123.
Ussia
,
M.
,
Urso
,
M.
,
Kratochvilova
,
M.
,
Navratil
,
J.
,
Balvan
,
J.
,
Mayorga‐Martinez
,
C. C.
,
Vyskocil
,
J.
,
Masarik
,
M.
, and
Pumera
,
M.
, 2023
, “
Magnetically Driven Self‐Degrading Zinc‐Containing Cystine Microrobots for Treatment of Prostate Cancer
,” Small
,
19
(17
), p. 2208259
.10.1002/smll.202208259124.
Martel
,
S.
,
Mohammadi
,
M.
,
Felfoul
,
O.
,
Lu
,
Z.
, and
Pouponneau
,
P.
, 2009
, “
Flagellated Magnetotactic Bacteria as Controlled MRI-Trackable Propulsion and Steering Systems for Medical Nanorobots Operating in the Human Microvasculature
,” Int. J. Rob. Res.
,
28
(4
), pp. 571
–582
.10.1177/0278364908100924125.
Magdanz
,
V.
,
Sanchez
,
S.
, and
Schmidt
,
O.
, 2013
, “
Development of a Sperm‐Flagella Driven Micro‐Bio‐Robot
,” Adv. Mater.
,
25
(45
), pp. 6581
–6588
.10.1002/adma.201302544126.
Yasa
,
O.
,
Erkoc
,
P.
,
Alapan
,
Y.
, and
Sitti
,
M.
, 2018
, “
Microalga‐Powered Microswimmers Toward Active Cargo Delivery
,” Adv. Mater.
,
30
(45
), p. 1804130
.10.1002/adma.201804130127.
Hawkeye
,
M. M.
, and
Brett
,
M. J.
, 2007
, “
Glancing Angle Deposition: Fabrication, Properties, and Applications of Micro- and Nanostructured Thin Films
,” J. Vac. Sci. Technol. A
,
25
(5
), pp. 1317
–1335
.10.1116/1.2764082128.
Brett
,
M. J.
, and
Hawkeye
,
M. M.
, 2008
, “
New Materials at a Glance
,” Science
,
319
(5867
), pp. 1192
–1193
.10.1126/science.1153910129.
Kadiri
,
V. M.
,
Bussi
,
C.
,
Holle
,
A. W.
,
Son
,
K.
,
Kwon
,
H.
,
Schütz
,
G.
,
Gutierrez
,
M. G.
, and
Fischer
,
P.
, 2020
, “
Biocompatible Magnetic Micro‐ and Nanodevices: Fabrication of FePt Nanopropellers and Cell Transfection
,” Adv. Mater.
,
32
(25
), p. 2001114
.10.1002/adma.202001114130.
Walker
,
D.
,
Käsdorf
,
B. T.
,
Jeong
,
H. H.
,
Lieleg
,
O.
, and
Fischer
,
P.
, 2015
, “
Enzymatically Active Biomimetic Micropropellers for the Penetration of Mucin Gels
,” Sci. Adv.
,
1
(11
), p. e1500501
.10.1126/sciadv.1500501131.
Wu
,
Z.
,
Troll
,
J.
,
Jeong
,
H. H.
,
Wei
,
Q.
,
Stang
,
M.
,
Ziemssen
,
F.
,
Wang
,
Z.
, et al., 2018
, “
A Swarm of Slippery Micropropellers Penetrates the Vitreous Body of the Eye
,” Sci. Adv.
,
4
(11
), p. eaat4388
.10.1126/sciadv.aat4388132.
Schamel
,
D.
,
Mark
,
A. G.
,
Gibbs
,
J. G.
,
Miksch
,
C.
,
Morozov
,
K. I.
,
Leshansky
,
A. M.
, and
Fischer
,
P.
, 2014
, “
Nanopropellers and Their Actuation in Complex Viscoelastic Media
,” ACS Nano
,
8
(9
), pp. 8794
–8801
.10.1021/nn502360t133.
Ghosh
,
A.
,
Paria
,
D.
,
Rangarajan
,
G.
, and
Ghosh
,
A.
, 2014
, “
Velocity Fluctuations in Helical Propulsion: How Small Can a Propeller Be
,” J. Phys. Chem. Lett.
,
5
(1
), pp. 62
–68
.10.1021/jz402186w134.
Liu
,
L.
,
Yoo
,
S. H.
,
Lee
,
S. A.
, and
Park
,
S.
, 2011
, “
Wet-Chemical Synthesis of Palladium Nanosprings
,” Nano Lett.
,
11
(9
), pp. 3979
–3982
.10.1021/nl202332x135.
Li
,
J.
,
Sattayasamitsathit
,
S.
,
Dong
,
R.
,
Gao
,
W.
,
Tam
,
R.
,
Feng
,
X.
,
Ai
,
S.
, and
Wang
,
J.
, 2014
, “
Template Electrosynthesis of Tailored-Made Helical Nanoswimmers
,” Nanoscale
,
6
(16
), pp. 9415
–9420
.10.1039/C3NR04760A136.
Hoop
,
M.
,
Shen
,
Y.
,
Chen
,
X. Z.
,
Mushtaq
,
F.
,
Iuliano
,
L. M.
,
Sakar
,
M. S.
,
Petruska
,
A.
,
Loessner
,
M. J.
,
Nelson
,
B. J.
, and
Pané
,
S.
, 2016
, “
Magnetically Driven Silver‐Coated Nanocoils for Efficient Bacterial Contact Killing
,” Adv. Funct. Mater.
,
26
(7
), pp. 1063
–1069
.10.1002/adfm.201504463137.
Li
,
J.
,
Angsantikul
,
P.
,
Liu
,
W.
,
Esteban‐Fernández de Ávila
,
B.
,
Chang
,
X.
,
Sandraz
,
E.
,
Liang
,
Y.
, et al., 2018
, “
Biomimetic Platelet‐Camouflaged Nanorobots for Binding and Isolation of Biological Threats
,” Adv. Mater.
,
30
(2
), p. 1704800
.10.1002/adma.201704800138.
Chen
,
X. Z.
,
Hoop
,
M.
,
Shamsudhin
,
N.
,
Huang
,
T.
,
Özkale
,
B.
,
Li
,
Q.
,
Siringil
,
E.
, et al., 2017
, “
Hybrid Magnetoelectric Nanowires for Nanorobotic Applications: Fabrication, Magnetoelectric Coupling, and Magnetically Assisted In Vitro Targeted Drug Delivery
,” Adv. Mater.
,
29
(8
), p. 1605458
.10.1002/adma.201605458139.
Jang
,
B.
,
Hong
,
A.
,
Alcantara
,
C.
,
Chatzipirpiridis
,
G.
,
Marti
,
X.
,
Pellicer
,
E.
,
Sort
,
J.
, et al., 2019
, “
Programmable Locomotion Mechanisms of Nanowires With Semihard Magnetic Properties Near a Surface Boundary
,” ACS Appl. Mater. Interfaces
,
11
(3
), pp. 3214
–3223
.10.1021/acsami.8b16907140.
Zhang
,
J.
,
Agramunt-Puig
,
S.
,
Del-Valle
,
N.
,
Navau
,
C.
,
Baro
,
M. D.
,
Estrade
,
S.
,
Peiró
,
F.
, et al., 2016
, “
Tailoring Staircase-Like Hysteresis Loops in Electrodeposited Trisegmented Magnetic Nanowires: A Strategy Toward Minimization of Interwire Interactions
,” ACS Appl. Mater. Interfaces
,
8
(6
), pp. 4109
–4117
.10.1021/acsami.5b11747141.
Mushtaq
,
F.
,
Asani
,
A.
,
Hoop
,
M.
,
Chen
,
X. Z.
,
Ahmed
,
D.
,
Nelson
,
B. J.
, and
Pané
,
S.
, 2016
, “
Highly Efficient Coaxial TiO2‐PtPd Tubular Nanomachines for Photocatalytic Water Purification With Multiple Locomotion Strategies
,” Adv. Funct. Mater.
,
26
(38
), pp. 6995
–7002
.10.1002/adfm.201602315142.
Ji
,
F.
,
Li
,
T.
,
Yu
,
S.
,
Wu
,
Z.
, and
Zhang
,
L.
, 2021
, “
Propulsion Gait Analysis and Fluidic Trapping of Swinging Flexible Nanomotors
,” ACS Nano
,
15
(3
), pp. 5118
–5128
.10.1021/acsnano.0c10269143.
Li
,
T.
,
Li
,
J.
,
Morozov
,
K. I.
,
Wu
,
Z.
,
Xu
,
T.
,
Rozen
,
I.
,
Leshansky
,
A. M.
,
Li
,
L.
, and
Wang
,
J.
, 2017
, “
Highly Efficient Freestyle Magnetic Nanoswimmer
,” Nano Lett.
,
17
(8
), pp. 5092
–5098
.10.1021/acs.nanolett.7b02383144.
Wu
,
J.
,
Jang
,
B.
,
Harduf
,
Y.
,
Chapnik
,
Z.
,
Avci
,
Ö. B.
,
Chen
,
X.
,
Puigmartí-Luis
,
J.
, et al., 2021
, “
Helical Klinotactic Locomotion of Two‐Link Nanoswimmers With Dual‐Function Drug‐Loaded Soft Polysaccharide Hinges
,” Adv. Sci.
,
8
(8
), p. 2004458
.10.1002/advs.202004458
