In the present work, we report the novel natural transdermal otoliths/collagen/bacterial cellulose patch for osteoporosis treatment. This biomaterial is an osteoinductor, or be, stimulates the bone regeneration, enabling bigger migration of the cells for formation of the bone fabric. Otolith is a typical biomaterial that is composed of calcium carbonate and organic matrix. Otoliths are calcareous concrescences present in the inner ear of fishes. Since they are rich in minerals, they are considered essential to the bone mineralization process on a protein matrix (otolin). The objective in this study was to analyze the regeneration capacity of bone defects treated with otoliths network preparation. Collagen and nano-otoliths influences in bacterial cellulose was analyzed using transmission infrared spectroscopy (FTIR). In vivo analysis shows bone surface tissue with high regularity, higher osteoblast activity, and osteo-reabsorption activities areas. These results indicated that the transdermal permeation of otollith using this patch system was sufficient for the treatment of bone diseases. These findings indicate that our novel transdermal delivery system for otolith/collagen/bacterial cellulose is a promising approach to improve compliance and quality of life of patients in the treatment of bone diseases.
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August 2011
Research Papers
Novel Natural Transdermal Otoliths/Collagen/Bacterial Cellulose Patch for Osteoporosis Treatment
Gabriel Molina de Olyveira,
Gabriel Molina de Olyveira
Department of Nanoscience and Advanced Materials-UFABC
, Rua Santa Adélia, 166, Santo André-SP, Brazil
, 09291-210
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Ligia Maria Manzine Costa,
Ligia Maria Manzine Costa
Department of Nanoscience and Advanced Materials-UFABC
, Rua Santa Adélia, 166, Santo André-SP, Brazil
, 09291-210
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Plácia Barreto Prata Góis,
Plácia Barreto Prata Góis
Natural Products and Biotechnology Laboratory, IPT, UNIT, Aracaju-Sergipe,
Brazil
, 49.032-490
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Pierre Basmaji,
Pierre Basmaji
Innovatec’s - Biotechnology Research and Development
, Sao Carlos, SP, Brazil
, 13566-610
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Lauro Xavier Filho
Lauro Xavier Filho
Natural Products and Biotechnology Laboratory, IPT, UNIT, Aracaju-Sergipe,
Brazil
, 49.032-490
Search for other works by this author on:
Gabriel Molina de Olyveira
Department of Nanoscience and Advanced Materials-UFABC
, Rua Santa Adélia, 166, Santo André-SP, Brazil
, 09291-210
Ligia Maria Manzine Costa
Department of Nanoscience and Advanced Materials-UFABC
, Rua Santa Adélia, 166, Santo André-SP, Brazil
, 09291-210
Plácia Barreto Prata Góis
Natural Products and Biotechnology Laboratory, IPT, UNIT, Aracaju-Sergipe,
Brazil
, 49.032-490
Pierre Basmaji
Innovatec’s - Biotechnology Research and Development
, Sao Carlos, SP, Brazil
, 13566-610
Lauro Xavier Filho
Natural Products and Biotechnology Laboratory, IPT, UNIT, Aracaju-Sergipe,
Brazil
, 49.032-490J. Nanotechnol. Eng. Med. Aug 2011, 2(3): 031011 (4 pages)
Published Online: January 26, 2012
Article history
Received:
April 24, 2011
Revised:
May 17, 2011
Online:
January 26, 2012
Published:
January 26, 2012
Citation
de Olyveira, G. M., Costa, L. M. M., Góis, P. B. P., Basmaji, P., and Xavier Filho, L. (January 26, 2012). "Novel Natural Transdermal Otoliths/Collagen/Bacterial Cellulose Patch for Osteoporosis Treatment." ASME. J. Nanotechnol. Eng. Med. August 2011; 2(3): 031011. https://doi.org/10.1115/1.4004306
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